BRENDA - Enzyme Database show

Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid

Matsuura, T.; Ross, A.C.; Arch. Biochem. Biophys. 301, 221-227 (1993)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.135
additional information
activation and mRNA expression for LRAT is blocked completely in vivo by actinomycin D; activation is blocked completely in vivo by cycloheximide
Rattus norvegicus
2.3.1.135
retinoic acid
optimal dose, 0.020 mg; restores normal level of liver LRAT activity in vitamin A deficient and depleted rats
Rattus norvegicus
2.3.1.135
Vitamin A
-
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Rattus norvegicus
-
vitamin A deficient and sufficient diet fed; vitamin A depleted diet fed
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
intestine
-
Rattus norvegicus
-
2.3.1.135
liver
undetectable in vitamin A depleted rats
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.3.1.135
0.000036
-
vitamin A-deficient rats treated orally with retinyl palmitate
Rattus norvegicus
2.3.1.135
0.0000401
-
vitamin A-deficient rats treated intraperitoneally with retinoic acid
Rattus norvegicus
2.3.1.135
0.0000415
-
vitamin A-deficient rats treated intraperitoneally with retinol
Rattus norvegicus
2.3.1.135
0.0000434
-
vitamin A-deficient rats treated orally with retinoic acid
Rattus norvegicus
2.3.1.135
0.0021
-
liver LRAT activity in vitamin A-deficient rats
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638614
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638614
Rattus norvegicus
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.135
additional information
activation and mRNA expression for LRAT is blocked completely in vivo by actinomycin D; activation is blocked completely in vivo by cycloheximide
Rattus norvegicus
2.3.1.135
retinoic acid
optimal dose, 0.020 mg; restores normal level of liver LRAT activity in vitamin A deficient and depleted rats
Rattus norvegicus
2.3.1.135
Vitamin A
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
intestine
-
Rattus norvegicus
-
2.3.1.135
liver
undetectable in vitamin A depleted rats
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.3.1.135
0.000036
-
vitamin A-deficient rats treated orally with retinyl palmitate
Rattus norvegicus
2.3.1.135
0.0000401
-
vitamin A-deficient rats treated intraperitoneally with retinoic acid
Rattus norvegicus
2.3.1.135
0.0000415
-
vitamin A-deficient rats treated intraperitoneally with retinol
Rattus norvegicus
2.3.1.135
0.0000434
-
vitamin A-deficient rats treated orally with retinoic acid
Rattus norvegicus
2.3.1.135
0.0021
-
liver LRAT activity in vitamin A-deficient rats
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638614
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638614
Rattus norvegicus
?