BRENDA - Enzyme Database show

A lecithin:retinol acyltransferase activity in human and rat liver

MacDonald, P.N.; Ong, D.E.; Biochem. Biophys. Res. Commun. 156, 157-163 (1988)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
N-ethylmaleimide
0.001 mM, complete inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Homo sapiens
2.3.1.135
N-ethylmaleimide
-
Rattus norvegicus
2.3.1.135
phenylmethylsulfonyl fluoride
2 mM, 90% inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Homo sapiens
2.3.1.135
phenylmethylsulfonyl fluoride
-
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.135
0.0005
-
retinol-(cellular-retinol-binding-protein)
reaction with phosphatidylcholine
Homo sapiens
2.3.1.135
0.001
-
retinol-(cellular-retinol-binding protein)
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.135
microsome
-
Homo sapiens
-
-
2.3.1.135
microsome
-
Rattus norvegicus
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Homo sapiens
-
-
-
2.3.1.135
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
liver
-
Homo sapiens
-
2.3.1.135
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638613
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638613
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638613
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638613
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
phosphatidylcholine selective
638613
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
phosphatidylcholine selective
638613
Rattus norvegicus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638613
Homo sapiens
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638613
Homo sapiens
?
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638613
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638613
Rattus norvegicus
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.3.1.135
37
-
-
Homo sapiens
2.3.1.135
37
-
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
N-ethylmaleimide
0.001 mM, complete inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Homo sapiens
2.3.1.135
N-ethylmaleimide
-
Rattus norvegicus
2.3.1.135
phenylmethylsulfonyl fluoride
2 mM, 90% inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Homo sapiens
2.3.1.135
phenylmethylsulfonyl fluoride
-
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.135
0.0005
-
retinol-(cellular-retinol-binding-protein)
reaction with phosphatidylcholine
Homo sapiens
2.3.1.135
0.001
-
retinol-(cellular-retinol-binding protein)
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.135
microsome
-
Homo sapiens
-
-
2.3.1.135
microsome
-
Rattus norvegicus
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
liver
-
Homo sapiens
-
2.3.1.135
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638613
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638613
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638613
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638613
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
phosphatidylcholine selective
638613
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
phosphatidylcholine selective
638613
Rattus norvegicus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638613
Homo sapiens
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638613
Homo sapiens
?
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638613
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638613
Rattus norvegicus
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.3.1.135
37
-
-
Homo sapiens
2.3.1.135
37
-
-
Rattus norvegicus