BRENDA - Enzyme Database show

Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins

Herr, F.M.; Ong, D.E.; Biochemistry 31, 6748-6755 (1992)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
Apo-cellular-retinol-binding protein
-
Rattus norvegicus
2.3.1.135
additional information
1% dimethylsulfoxide does not inhibit LRAT activity
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.135
0.0002
-
retinol-(cellular-retinol-binding protein)
intestinal LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00024
-
retinol-(cellular-retinol-binding protein) type II
intestinal LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00032
-
retinol-cellular-retinol-binding protein type II
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00044
-
retinol
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00063
-
retinol
intestinal LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00078
-
retinol-(cellular-retinol-binding protein)
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
Rattus norvegicus
important role in absorption and storage of vitamin A
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
intestine
-
Rattus norvegicus
-
2.3.1.135
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638612
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638612
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
phosphatidylcholine selective
638612
Rattus norvegicus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638612
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
638612
Rattus norvegicus
?
2.3.1.135
phosphatidylcholine + all-trans-retinol
important role in absorption and storage of vitamin A
638612
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding protein) type II
-
638612
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) type II
-
-
-
?
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638612
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638612
Rattus norvegicus
?
Temperature Optimum [C]
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.3.1.135
37
-
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
Apo-cellular-retinol-binding protein
-
Rattus norvegicus
2.3.1.135
additional information
1% dimethylsulfoxide does not inhibit LRAT activity
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.3.1.135
0.0002
-
retinol-(cellular-retinol-binding protein)
intestinal LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00024
-
retinol-(cellular-retinol-binding protein) type II
intestinal LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00032
-
retinol-cellular-retinol-binding protein type II
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00044
-
retinol
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00063
-
retinol
intestinal LRAT, reaction with phosphatidylcholine
Rattus norvegicus
2.3.1.135
0.00078
-
retinol-(cellular-retinol-binding protein)
liver LRAT, reaction with phosphatidylcholine
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
Rattus norvegicus
important role in absorption and storage of vitamin A
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
intestine
-
Rattus norvegicus
-
2.3.1.135
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638612
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638612
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
phosphatidylcholine selective
638612
Rattus norvegicus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638612
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
638612
Rattus norvegicus
?
2.3.1.135
phosphatidylcholine + all-trans-retinol
important role in absorption and storage of vitamin A
638612
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding protein) type II
-
638612
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) type II
-
-
-
?
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638612
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638612
Rattus norvegicus
?
Temperature Optimum [C] (protein specific)
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.3.1.135
37
-
-
Rattus norvegicus