BRENDA - Enzyme Database show

Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine

MacDonald, P.N.; Ong, D.E.; J. Biol. Chem. 263, 12478-12482 (1988)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
N-ethylmaleimide
0.003 mM, complete inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Rattus norvegicus
2.3.1.135
p-chloromercuribenzoic acid
0.005 mM, complete inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Rattus norvegicus
2.3.1.135
phenylmethylsulfonyl fluoride
1 mM, 90% inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
intestinal mucosa
-
Rattus norvegicus
-
2.3.1.135
small intestine
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
1-lauroyl-2-myristoylphosphatidylcholine + retinol-(cellular-retinol-binding-protein)type II
-
638609
Rattus norvegicus
retinyl laurate-(cellular-retinol-binding-protein)type II + 2-myristoylphosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
1-myristoyl-2-lauroylphosphatidylcholine + retinol-(cellular-retinol-binding-protein)type II
-
638609
Rattus norvegicus
retinyl myristate-(cellular-retinol-binding-protein)type II + 2-lauroylphosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
1-palmitoyl-2-decanoylphosphatidylcholine + retinol-(cellular-retinol-binding-protein)type II
-
638609
Rattus norvegicus
retinyl palmitate-(cellular-retinol-binding-protein)type II + 2-decanoylphosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
dilauroylphosphatidylcholine + retinol-(cellular retinol binding protein)type II
-
638609
Rattus norvegicus
retinyl laurate-(cellular retinol binding protein)type II + 2-lauroyl-phosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
dimyristoylphosphatidic acid + retinol-(cellular retinol binding protein) type II
little if any retinyl myristate obtained
638609
Rattus norvegicus
retinyl myristate + myristoylphosphatidic acid
-
638609
Rattus norvegicus
?
2.3.1.135
dimyristoylphosphatidylcholine + retinol(cellular retinol binding protein)type II
-
638609
Rattus norvegicus
retinyl myristate-(cellular retinol binding protein)type II + 2-myristoyl-phosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
dimyristoylphosphatidylethanolamine + retinol-(cellular retinol binding protein) type II
little if any retinyl myristate obtained
638609
Rattus norvegicus
retinyl myristate-(cellular retinol binding protein)type II + myristoyl-phosphatidylethanolamine
-
638609
Rattus norvegicus
?
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638609
Rattus norvegicus
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638609
Rattus norvegicus
?
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638609
Rattus norvegicus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding protein) type II
reaction with free fatty acid, fatty acyl-CoA, phosphatidic acid or ethanolamine as acyl donors
638609
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) type II
-
638609
Rattus norvegicus
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
N-ethylmaleimide
0.003 mM, complete inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Rattus norvegicus
2.3.1.135
p-chloromercuribenzoic acid
0.005 mM, complete inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Rattus norvegicus
2.3.1.135
phenylmethylsulfonyl fluoride
1 mM, 90% inhibition of retinol-(cellular-retinol-binding-protein)type II esterification
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
intestinal mucosa
-
Rattus norvegicus
-
2.3.1.135
small intestine
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
1-lauroyl-2-myristoylphosphatidylcholine + retinol-(cellular-retinol-binding-protein)type II
-
638609
Rattus norvegicus
retinyl laurate-(cellular-retinol-binding-protein)type II + 2-myristoylphosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
1-myristoyl-2-lauroylphosphatidylcholine + retinol-(cellular-retinol-binding-protein)type II
-
638609
Rattus norvegicus
retinyl myristate-(cellular-retinol-binding-protein)type II + 2-lauroylphosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
1-palmitoyl-2-decanoylphosphatidylcholine + retinol-(cellular-retinol-binding-protein)type II
-
638609
Rattus norvegicus
retinyl palmitate-(cellular-retinol-binding-protein)type II + 2-decanoylphosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
dilauroylphosphatidylcholine + retinol-(cellular retinol binding protein)type II
-
638609
Rattus norvegicus
retinyl laurate-(cellular retinol binding protein)type II + 2-lauroyl-phosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
dimyristoylphosphatidic acid + retinol-(cellular retinol binding protein) type II
little if any retinyl myristate obtained
638609
Rattus norvegicus
retinyl myristate + myristoylphosphatidic acid
-
638609
Rattus norvegicus
?
2.3.1.135
dimyristoylphosphatidylcholine + retinol(cellular retinol binding protein)type II
-
638609
Rattus norvegicus
retinyl myristate-(cellular retinol binding protein)type II + 2-myristoyl-phosphatidylcholine
-
638609
Rattus norvegicus
?
2.3.1.135
dimyristoylphosphatidylethanolamine + retinol-(cellular retinol binding protein) type II
little if any retinyl myristate obtained
638609
Rattus norvegicus
retinyl myristate-(cellular retinol binding protein)type II + myristoyl-phosphatidylethanolamine
-
638609
Rattus norvegicus
?
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638609
Rattus norvegicus
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638609
Rattus norvegicus
?
2.3.1.135
additional information
little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein)
638609
Rattus norvegicus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding protein) type II
reaction with free fatty acid, fatty acyl-CoA, phosphatidic acid or ethanolamine as acyl donors
638609
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) type II
-
638609
Rattus norvegicus
?