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Literature summary extracted from

  • Goalstone, M.L.; Leitner, J.W.; Golovchenko, I.; Stjernholm, M.R.; Cormont, M.; Le Marchand-Brustel, Y.; Draznin, B.
    Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4 (1999), J. Biol. Chem., 274, 2880-2884.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.60 Insulin promotes the phosphorylation of the alpha subunit of enzyme without an effect on beta subunit, and activation of enzyme, insulin increases the amount of geranylgeranylated Rab3 and Rab4 proteins Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.60 additional information perillyl alcohol inhibits insulin induced activation of enzyme, but not GGTI-298 and alpha-hxdroxyfarnesylphosphonic acid, PD 98056 inhibits the ability of insulin to increase the amount of geranylgeranylated Rab3 and Rab4 proteins Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine Mus musculus enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking S-geranylgeranyl-protein + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.60 adipocyte
-
 Mus musculus
-
2.5.1.60 fibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine substrate are Rab3 and Rab4 Mus musculus S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking Mus musculus S-geranylgeranyl-protein + diphosphate
-
 ?