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Literature summary extracted from

  • Thomä, N.H.; Niculae, A.; Goody, R.S.; Alexandrov, K.
    Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate (2001), J. Biol. Chem., 276, 48631-48636.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.60 expression in SF21 cells Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Rattus norvegicus
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-
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Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate mechanism, phosphoisoprenoid acts both as a substrate and as a sensor governing the kinetics of protein protein interactions in the double prenylation reaction Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine
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Rattus norvegicus S-geranylgeranyl-protein + diphosphate
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?
2.5.1.60 additional information the affinity of the mono-prenylated Rab7/REP-1 complex is very close to that observed for double prenylated Rab7/REP-1 complex binding to enzyme Rattus norvegicus ?
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?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.60 additional information
-
additional information double prenylation the rate for the first prenyl transfer reaction is 0.00026/min, while the second prenyl transfer reaction is 4fold slower Rattus norvegicus