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Literature summary extracted from

  • Palcic, M.M.; Ripka, J.; Kaur, K.J.; Shoreibah, M.; Hindsgaul, O.; Pierce, M.
    Regulation of N-acetylglucosaminyltransferase V activity. Kinetic comparisons of parental, Rous sarcoma virus-transformed BHK, and L-phytohemagglutinin-resistant BHK cells using synthetic substrates and an inhibitory substrate analog (1990), J. Biol. Chem., 265, 6759-6769.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.155 N-Acetyl-D-glucosaminyl-1,2-alpha-6-deoxy-mannosyl-1,6-beta-D-glucosyl-O-(CH2)7-CH3
-
 Mesocricetus auratus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.155 1.1 1.2 UDP-N-acetylglucosamine
-
 Mesocricetus auratus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.155 membrane
-
 Mesocricetus auratus 16020
-
2.4.1.155 microsome
-
 Mesocricetus auratus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.155 additional information no requirement for Mn2+ Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.155 UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R Mesocricetus auratus involved in biosynthesis of branched N-glycopeptides UDP + N-acetyl-D-glucosaminyl-1,2-(N-acetyl-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.155 Mesocricetus auratus
-
 hamster
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.155 BHK-21 cell native BHK-21/c13 cells, cells transformed with Rous sarcoma virus, i.e. RS-BHK-cells, and lectin-resistant cell-lines LP 1.6 and 3.3 Mesocricetus auratus
-
2.4.1.155 kidney
-
 Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.155 additional information
-
-
 Mesocricetus auratus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.155 UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R synthetic acceptor substrates Mesocricetus auratus UDP + N-acetyl-D-glucosaminyl-1,2-(N-acetyl-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?
2.4.1.155 UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R involved in biosynthesis of branched N-glycopeptides Mesocricetus auratus UDP + N-acetyl-D-glucosaminyl-1,2-(N-acetyl-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.155 37
-
 assay at Mesocricetus auratus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.155 0.06 0.077 N-Acetyl-D-glucosaminyl-1,2-alpha-6-deoxy-mannosyl-1,6-beta-D-glucosyl-O-(CH2)7-CH3
-
 Mesocricetus auratus