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Literature summary extracted from

  • Gentzsch, M.; Tanner, W.
    Protein-O-glycosylation in yeast: protein-specific mannosyltransferases (1997), Glycobiology, 7, 481-486.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.109 additional information construction of defective mutants of PMT1-4,6, determination of substrate specificities Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.109 dolichyl phosphate D-mannose + protein Saccharomyces cerevisiae acceptor substrate specificities of PMT1-4,6 dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Aga2 Saccharomyces cerevisiae i.e. small-agglutinin dolichyl phosphate + O-D-mannosylprotein Aga2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Aga2 Saccharomyces cerevisiae activity is not affected by disruption mutations of PMT1-4 dolichyl phosphate + O-D-mannosylprotein Aga2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Aga2 Saccharomyces cerevisiae protein is located at the cell surface dolichyl phosphate + O-D-mannosylprotein Aga2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Bar1 Saccharomyces cerevisiae PMT1 and PMT2, not PMT3 and PMT4 dolichyl phosphate + O-D-mannosylprotein Bar1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Bar1 Saccharomyces cerevisiae protein is located in the medium dolichyl phosphate + O-D-mannosylprotein Bar1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein chitinase 1 Saccharomyces cerevisiae PMT1, PMT4, PMT6 and especially PMT2, not PMT3 dolichyl phosphate + O-D-mannosylprotein chitinase 1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein chitinase 1 Saccharomyces cerevisiae protein is located in the cell wall and medium dolichyl phosphate + O-D-mannosylprotein chitinase 1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Ggp1/Gas1 Saccharomyces cerevisiae PMT4 and PMT6, not PMT1-3 dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Ggp1/Gas1 Saccharomyces cerevisiae protein is located at the cell surface dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kex2 Saccharomyces cerevisiae PMT4, not PMT1-3 dolichyl phosphate + O-D-mannosylprotein Kex2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kex2 Saccharomyces cerevisiae protein is located in the Golgi apparatus dolichyl phosphate + O-D-mannosylprotein Kex2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kre9 Saccharomyces cerevisiae mainly PMT1 and PMT2, not PMT3 and PMT4 dolichyl phosphate + O-D-mannosylprotein Kre9
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kre9 Saccharomyces cerevisiae protein is located in the Golgi apparatus dolichyl phosphate + O-D-mannosylprotein Kre9
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Pir2/hsp150 Saccharomyces cerevisiae PMT1, PMT2, and to some extent PMT4, not PMT3 dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Pir2/hsp150 Saccharomyces cerevisiae protein is located in the medium dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150
-
 ?
2.4.1.109 additional information Saccharomyces cerevisiae defective mutants are used to investigate the substrate specificities of PMT1-4,6 in vivo ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.109 Saccharomyces cerevisiae
-
 genes PMT1-6
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.109 dolichyl phosphate D-mannose + AcSSSSSNH2 PMT1-3, PMT5, PMT6, not PMT4 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosyl-AcSSSSSNH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein the enzyme transfers mannosyl residues to the hydroxyl of serine or threonine residues Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein acceptor substrate specificities of PMT1-4,6 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Aga2 i.e. small-agglutinin Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Aga2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Aga2 activity is not affected by disruption mutations of PMT1-4 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Aga2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Aga2 protein is located at the cell surface Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Aga2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Bar1 PMT1 and PMT2, not PMT3 and PMT4 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Bar1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Bar1 protein is located in the medium Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Bar1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein chitinase 1 PMT1, PMT4, PMT6 and especially PMT2, not PMT3 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein chitinase 1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein chitinase 1 protein is located in the cell wall and medium Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein chitinase 1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Ggp1/Gas1 PMT4 and PMT6, not PMT1-3 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Ggp1/Gas1 protein is located at the cell surface Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Ggp1/Gas1
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kex2 PMT4, not PMT1-3 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Kex2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kex2 protein is located in the Golgi apparatus Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Kex2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kre9 mainly PMT1 and PMT2, not PMT3 and PMT4 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Kre9
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Kre9 protein is located in the Golgi apparatus Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Kre9
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Pir2/hsp150 PMT1, PMT2, and to some extent PMT4, not PMT3 Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Pir2/hsp150 protein is located in the medium Saccharomyces cerevisiae dolichyl phosphate + O-D-mannosylprotein Pir2/hsp150
-
 ?
2.4.1.109 additional information PMT3: no clearly determined dolichyl-phosphate-mannose-protein mannosyltransferase activity Saccharomyces cerevisiae ?
-
 ?
2.4.1.109 additional information PMT4 and PMT6 probably function as an active dimer Saccharomyces cerevisiae ?
-
 ?
2.4.1.109 additional information PMT1 and PMT2 function as a complex Saccharomyces cerevisiae ?
-
 ?
2.4.1.109 additional information defective mutants are used to investigate the substrate specificities of PMT1-4,6 in vivo Saccharomyces cerevisiae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.109 More PMT4 and PMT6 probably function as an active dimer Saccharomyces cerevisiae
2.4.1.109 More PMT1 and PMT2 function as a complex Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
2.4.1.109 More PMT3: no clearly determined dolichyl-phosphate-mannose-protein mannosyltransferase activity Saccharomyces cerevisiae
2.4.1.109 PMT
-
 Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.109 6.5
-
 assay at Saccharomyces cerevisiae