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Literature summary extracted from

  • Weston, A.; Nassau, P.M.; Henley, C.; Marriott, M.S.
    Protein O-mannosylation in Candida albicans. Determination of the amino acid sequences of peptide acceptors for protein O-mannosyltransferase (1993), Eur. J. Biochem., 215, 845-849.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.109 phosphatidylcholine stimulates Candida albicans

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.109 Mg2+ above 5 mM Candida albicans
2.4.1.109 phosphatidylinositol
-
 Candida albicans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.109 0.075
-
 biotin-Tyr-Thr-Ala-Val-NH2
-
 Candida albicans
2.4.1.109 0.1
-
 biotin-Tyr-Leu-Ala-Val-NH2
-
 Candida albicans
2.4.1.109 0.25
-
 Ac-Tyr-Ala-Thr-Ala-Val-NH2
-
 Candida albicans
2.4.1.109 0.85
-
 biotin-Tyr-Pro-Thr-Ala-Val-NH2
-
 Candida albicans
2.4.1.109 2.2
-
 Tyr-Ala-Thr-Ala-Val
-
 Candida albicans
2.4.1.109 2.5
-
 Tyr-Leu-Thr-Ala-Val
-
 Candida albicans
2.4.1.109 4.3
-
 Ac-Tyr-Asn-Pro-Thr-Ser-Val-NH2
-
 Candida albicans
2.4.1.109 6.7
-
 Ac-Ala-Thr-Ala-NH2
-
 Candida albicans
2.4.1.109 7.3
-
 Tyr-Pro-Thr-Ala-Val
-
 Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.109 membrane
-
 Candida albicans 16020
-
2.4.1.109 microsome
-
 Candida albicans
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.109 Mg2+ not required Candida albicans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.109 dolichyl phosphate D-mannose + protein Candida albicans production of cell-wall mannoproteins dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein Candida albicans 2005 E production of cell-wall mannoproteins dolichyl phosphate + O-D-mannosylprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.109 Candida albicans
-
 2005 E
-
2.4.1.109 Candida albicans 2005 E
-
 2005 E
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.109 0.0000012
-
 substrate YNPTSV Candida albicans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.109 dolichyl beta-D-mannosyl phosphate + biotin-Tyr-Leu-Ala-Val-NH2
-
 Candida albicans ?
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Ac-Ala-Thr-Ala-NH2
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-Ac-Ala-Thr-Ala-NH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Ac-Tyr-Ala-Thr-Ala-Val-NH2
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-Ac-Tyr-Ala-Thr-Ala-Val-NH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Ac-Tyr-Asn-Pro-Thr-Ser-Val-NH2
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-Ac-Tyr-Asn-Pro-Thr-Ser-Val-NH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Ac-Tyr-Asn-Pro-Thr-Ser-Val-NH2
-
 Candida albicans 2005 E dolichyl phosphate + O-D-mannosyl-Ac-Tyr-Asn-Pro-Thr-Ser-Val-NH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + biotin-Tyr-Ala-Thr-Ala-Val-NH2
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-N-biotinyl-Tyr-Ala-Thr-Ala-Val-NH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + biotin-Tyr-Pro-Thr-Ala-Val-NH2
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-N-biotinyl-Tyr-Pro-Thr-Ala-Val-NH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + biotin-Tyr-Thr-Ala-Val-NH2
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-N-biotinyl-Tyr-Thr-Ala-Val-NH2
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein
-
 Candida albicans dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein the enzyme transfers mannosyl residues to the hydroxyl of serine or threonine residues Candida albicans dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein production of cell-wall mannoproteins Candida albicans dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein
-
 Candida albicans 2005 E dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein the enzyme transfers mannosyl residues to the hydroxyl of serine or threonine residues Candida albicans 2005 E dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + protein production of cell-wall mannoproteins Candida albicans 2005 E dolichyl phosphate + O-D-mannosylprotein
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Tyr-Ala-Thr-Ala-Val
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-Tyr-Ala-Thr-Ala-Val
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Tyr-Asn-Pro-Thr-Ser-Val
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-Tyr-Asn-Pro-Thr-Ser-Val
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Tyr-Asn-Pro-Thr-Ser-Val
-
 Candida albicans 2005 E dolichyl phosphate + O-D-mannosyl-Tyr-Asn-Pro-Thr-Ser-Val
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Tyr-Leu-Thr-Ala-Val
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-Tyr-Leu-Thr-Ala-Val
-
 ?
2.4.1.109 dolichyl phosphate D-mannose + Tyr-Pro-Thr-Ala-Val
-
 Candida albicans dolichyl phosphate + O-D-mannosyl-Tyr-Pro-Thr-Ala-Val
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.109 25
-
 assay at Candida albicans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.109 7.5 8 the best buffers are bicine pH 7.7, tricine pH 8.0 and HEPES pH 7.5 Candida albicans