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Literature summary extracted from

  • Toki, D.; Granovsky, M.A.; Reck, F.; Kuhns, W.; Baker, M.A.; Matta, K.L.; Brockhausen, I.
    Inhibition of UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from acute myeloid leukaemia cells by photoreactive nitrophenyl substrate derivatives (1994), Biochem. Biophys. Res. Commun., 198, 417-423.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.102 molecular biology beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl and other nitrophenyl-sugar-derivatives are useful as specific inhibitors and as affinity label Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.102 beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl and other nitrophenyl-sugar-derivatives; strong inhibition under UV-radiation at 350 nm, specific for substrate binding site, preincubation with beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl partially protects Homo sapiens
2.4.1.102 substrate analogues lacking the 6-hydroxyl of the N-acetylgalactosamine weak Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.102 microsome
-
 Homo sapiens
-
-
2.4.1.102 microsome
-
 Rattus norvegicus
-
-
2.4.1.102 microsome
-
 Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.102 additional information Rattus norvegicus
-
 ?
-
 ?
2.4.1.102 additional information Sus scrofa
-
 ?
-
 ?
2.4.1.102 additional information Homo sapiens enzyme activity is increased in patients with chronic myelogenous leukemia CML or acute myeloid leukemia AML ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.102 Homo sapiens
-
-
-
2.4.1.102 Rattus norvegicus
-
-
-
2.4.1.102 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.102 acute myeloid leukemia cell acute myeloid leukemia blast cell line Homo sapiens
-
2.4.1.102 colon
-
 Homo sapiens
-
2.4.1.102 colon
-
 Rattus norvegicus
-
2.4.1.102 colon
-
 Sus scrofa
-
2.4.1.102 gastric mucosa
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.102 additional information
-
 Rattus norvegicus ?
-
 ?
2.4.1.102 additional information
-
 Sus scrofa ?
-
 ?
2.4.1.102 additional information enzyme activity is increased in patients with chronic myelogenous leukemia CML or acute myeloid leukemia AML Homo sapiens ?
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
 Homo sapiens ?
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
 Rattus norvegicus ?
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-(6-deoxy)-N-acetyl-D-galactosaminyl-benzyl
-
 Sus scrofa ?
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 Rattus norvegicus UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 Sus scrofa UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?
2.4.1.102 UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl inhibitory under UV-radiation Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?