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Literature summary extracted from

  • Rudd, P.M.; Endo, T.; Colominas, C.; Groth, D.; Wheeler, S.F.; Harvey, D.J.; Wormald, M.R.; Serban, H.; Prusiner, S.B.; Kobata, A.; Dwek, R.A.
    Glycosylation differences between the normal and pathogenic prion protein isoforms (1999), Proc. Natl. Acad. Sci. USA, 96, 13044-13049.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.144 additional information Mesocricetus auratus in brain cells with down-regulated enzyme activity, normal prion proteins PrPC get conversed to pathogenic prion protein PrPSc due to a lower amount of glycans with bisecting N-acetylglucosamine residues ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.144 Mesocricetus auratus
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 forming normal prion protein PrPC and pathogenic prion protein PrPSc
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.144 brain cells forming normal prion protein PrPC with normal enzyme activity, and pathogenic prion protein PrPSc with reduced enzyme activity Mesocricetus auratus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.144 additional information in brain cells with down-regulated enzyme activity, normal prion proteins PrPC get conversed to pathogenic prion protein PrPSc due to a lower amount of glycans with bisecting N-acetylglucosamine residues Mesocricetus auratus ?
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 ?
2.4.1.144 UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
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 Mesocricetus auratus UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R incorporates a N-acetylglucosamine residue in beta-1,4-linkage to beta-linked mannosyl, i.e. bisecting N-acetylglucosamine ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.144 GnTIII
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 Mesocricetus auratus