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Literature summary extracted from

  • Park, J.H.; Wolff, E.C.; Folk, E.C.; Park, M.H.
    Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase (2003), J. Biol. Chem., 278, 32683-32691.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.46 1,7-Diaminoheptane inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
2.5.1.46 6,6'-difluorospermidine inhibition of deoxyhypusine synthesis Homo sapiens
2.5.1.46 aminopropylcadaverine inhibition of deoxyhypusine synthesis Homo sapiens
2.5.1.46 caldine inhibition of deoxyhypusine synthesis Homo sapiens
2.5.1.46 Homospermidine inhibition of deoxyhypusine synthesis Homo sapiens
2.5.1.46 N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene
-
 Homo sapiens
2.5.1.46 N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene
-
 Homo sapiens
2.5.1.46 N1-ethylspermidine inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
2.5.1.46 N1-guanyl-1,7-diaminoheptane inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
2.5.1.46 N1-methylspermidine inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens
2.5.1.46 spermidine inhibits generation of spermidine from [eIF5A-precursor]-deoxyhypusine Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.46 0.0015
-
 putrescine
-
 Homo sapiens
2.5.1.46 0.0066
-
 [eIF5A-precursor]-deoxyhypusine pH 7.5 Homo sapiens
2.5.1.46 0.00726
-
 spermidine reaction with eIF5A-precursor Homo sapiens
2.5.1.46 0.0086
-
 [eIF5A-precursor]-deoxyhypusine pH 9.5 Homo sapiens
2.5.1.46 0.0193
-
 homospermine
-
 Homo sapiens
2.5.1.46 0.028
-
 spermidine reaction with putrescine Homo sapiens
2.5.1.46 0.0954
-
 1,3-diaminopropane pH 7.5 Homo sapiens
2.5.1.46 0.1058
-
 1,3-diaminopropane pH 9.5 Homo sapiens
2.5.1.46 0.203
-
 putrescine
-
 Homo sapiens
2.5.1.46 1.12
-
 [eIF5A-precursor]-L-lysine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 1-ethylspermidine + putrescine
-
 Homo sapiens homospermidine + ?
-
 ?
2.5.1.46 1-ethylspermidine + [eIF5A-precursor]-lysine
-
 Homo sapiens [eIF5A-precursor]-deoxyhypusine + ?
-
 ?
2.5.1.46 1-methylspermidine + putrescine
-
 Homo sapiens homospermidine + ?
-
 ?
2.5.1.46 1-methylspermidine + [eIF5A-precursor]-lysine
-
 Homo sapiens [eIF5A-precursor]-deoxyhypusine + ?
-
 ?
2.5.1.46 8-ethylspermidine + putrescine
-
 Homo sapiens ethylhomospermidine + ?
-
 ?
2.5.1.46 8-ethylspermidine + [eIF5A-precursor]-lysine
-
 Homo sapiens [eIF5A-precursor]-ethyldeoxyhypusine + ?
-
 ?
2.5.1.46 8-methylspermidine + putrescine
-
 Homo sapiens methylhomospermidine + ?
-
 ?
2.5.1.46 8-methylspermidine + [eIF5A-precursor]-lysine
-
 Homo sapiens [eIF5A-precursor]-methyldeoxyhypusine + ?
-
 ?
2.5.1.46 aminopropylcadaverine + [eIF5A-precursor]-lysine
-
 Homo sapiens [eIF5A-precursor]-homodeoxyhypusine + ?
-
 ?
2.5.1.46 caldine + putrescine
-
 Homo sapiens spermidine + ?
-
 ?
2.5.1.46 homospermidine + putrescine
-
 Homo sapiens homospermidine + ?
-
 ?
2.5.1.46 homospermidine + [eIF5A-precursor]-lysine
-
 Homo sapiens [eIF5A-precursor]-deoxyhypusine + ?
-
 ?
2.5.1.46 homospermine + [eIF5A-precursor]-lysine
-
 Homo sapiens ?
-
 ?
2.5.1.46 N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene + putrescine
-
 Homo sapiens (1Z)-N4-(4-aminobutyl)but-1-ene-1,4-diamine + 1,3-diaminopropane
-
 ?
2.5.1.46 N-(3-aminopropyl)-1,4-diamino-cis-but-2-ene + [eIF5A-precursor]-lysine
-
 Homo sapiens ?
-
 ?
2.5.1.46 N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene + putrescine
-
 Homo sapiens (1E)-N4-(4-aminobutyl)but-1-ene-1,4-diamine + 1,3-diaminopropane
-
 ?
2.5.1.46 N-(3-aminopropyl)-1,4-diamino-trans-but-2-ene + [eIF5A-precursor]-lysine
-
 Homo sapiens ?
-
 ?
2.5.1.46 spermidine + putrescine
-
 Homo sapiens homospermidine + ?
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine reversal of reaction in presence of NAD+ Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine r

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.46 NAD+
-
 Homo sapiens