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Literature summary extracted from

  • Jakus, J.; Wolff, E.C.; Park, M.H.; Folk, J.E.
    Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines (1993), J. Biol. Chem., 268, 13151-13159.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.46 1,3-diaminopropane
-
Rattus norvegicus
2.5.1.46 1,7-Diaminoheptane
-
Rattus norvegicus
2.5.1.46 1,8-diaminooctane
-
Rattus norvegicus
2.5.1.46 1-(3-aminopropyl)-4-aminomethylpiperidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 1-aminooctane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 1-methylspermidine 0.184 mM, 50% inhibition Rattus norvegicus
2.5.1.46 6,6'-difluorospermidine 0.014 mM, 50% inhibition Rattus norvegicus
2.5.1.46 6-fluorospermidine 0.048 mM, 50% inhibition Rattus norvegicus
2.5.1.46 7,7-Difluorospermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 caldine
-
Rattus norvegicus
2.5.1.46 guazatine
-
Rattus norvegicus
2.5.1.46 hirudonine
-
Rattus norvegicus
2.5.1.46 N,N'-bis-benzyldiaminooctane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N-(2-cyanoethyl)-1,3-diaminopropane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N-(3-aminopropyl)-1,3-diaminopropane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N-(3-aminopropyl)-cadaverine
-
Rattus norvegicus
2.5.1.46 N-(3-aminopropyl)-cis-1,4-diaminocyclohexane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N-(3-aminopropyl)-trans-1,4-diaminocyclohexane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N-(3-cyanopropyl)-1,3-diaminopropane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N-butyl-1,3-diaminopropane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1,N3-bis-guanyl-1,3-diaminopropane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1,N3-bis-tert-butyloxycarbonylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1,N6-bis-guanyl-1,6-diaminohexane
-
Rattus norvegicus
2.5.1.46 N1,N7-bis-allylcaldine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1,N7-bis-benzylcaldine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1,N7-bis-dimethylcaldine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1,N7-bis-guanyl-1,7-diaminoheptane
-
Rattus norvegicus
2.5.1.46 N1,N7-bis-guanylcaldine
-
Rattus norvegicus
2.5.1.46 N1,N8-bis-guanyl-1,8-diaminooctane
-
Rattus norvegicus
2.5.1.46 N1-acetylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1-ethylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1-guanyl-1,3-diaminopropane 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N1-guanyl-1,7-diaminoheptane
-
Rattus norvegicus
2.5.1.46 N1-guanyl-1,8-diaminooctane
-
Rattus norvegicus
2.5.1.46 N1-guanylcaldine
-
Rattus norvegicus
2.5.1.46 N1-guanylspermine
-
Rattus norvegicus
2.5.1.46 N3-ethylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N4-(3-aminopropyl)-4-methylpentane-1,4-diamine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N4-acetylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N4-benzoylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N4-benzylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N4-bromoacetylspermidine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 N4-methylcaldine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 putrescine 1 mM, less than 50% inhibition Rattus norvegicus
2.5.1.46 spermidine
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.46 testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
Rattus norvegicus [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.46 NAD+
-
Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.46 0.0000097
-
N1-guanyl-1,7-diaminoheptane
-
Rattus norvegicus
2.5.1.46 0.00024
-
N1-guanyl-1,8-diaminooctane
-
Rattus norvegicus
2.5.1.46 0.00033
-
N1-guanylspermine
-
Rattus norvegicus
2.5.1.46 0.00074
-
N1-guanylcaldine
-
Rattus norvegicus
2.5.1.46 0.0017
-
N1,N7-bis-guanyl-1,7-diaminoheptane
-
Rattus norvegicus
2.5.1.46 0.00489
-
hirudonine
-
Rattus norvegicus
2.5.1.46 0.00565
-
N1,N8-bis-guanyl-1,8-diaminooctane
-
Rattus norvegicus
2.5.1.46 0.012
-
guazatine
-
Rattus norvegicus
2.5.1.46 0.035
-
N1,N6-bis-guanyl-1,6-diaminohexane
-
Rattus norvegicus
2.5.1.46 0.1545
-
N1,N7-bis-guanylcaldine
-
Rattus norvegicus