Literature summary extracted from

Wolff, E.C.; Lee, Y.B.; Chung, S.I.; Folk, J.E.; Park, M.H.
Deoxyhypusine synthase from rat testis: purification and characterization (1995), J. Biol. Chem., 270, 8660-8666.

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
2.5.1.46	40800	-	4 * 40800, MALDI mass spectrometry	Rattus norvegicus
2.5.1.46	144000	180000	gel filtration, sedimentation equilibrium centrifugation	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.46	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.5.1.46	testis	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.46	spermidine	reaction in absence of eIF5A-precursor	Rattus norvegicus	1,3-diaminopropane + DELTA1-pyrroline	-	?
2.5.1.46	[eIF5A-precursor]-lysine + spermidine	-	Rattus norvegicus	[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine	i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine	?

Subunits

EC Number	Subunits	Comment	Organism
2.5.1.46	tetramer	4 * 40800, MALDI mass spectrometry	Rattus norvegicus

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.5.1.46	9.5	9.6	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.5.1.46	NAD+	specific for NAD+	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)