Literature summary extracted from

Park, M.H.; Joe, Y.A.; Kang, K.R.
Deoxyhypusine synthase activity is essential for cell viability in the yeast Saccharomyces cerevisiae (1998), J. Biol. Chem., 273, 1677-1683.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.5.1.46	-	Saccharomyces cerevisiae

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.5.1.46	K308R/K350E	no activity	Saccharomyces cerevisiae
2.5.1.46	K308R/K350P	no activity	Saccharomyces cerevisiae
2.5.1.46	K308R/K350R	no activity	Saccharomyces cerevisiae
2.5.1.46	K350R	no activity	Saccharomyces cerevisiae

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.46	Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.46	[eIF5A-precursor]-lysine + spermidine	-	Saccharomyces cerevisiae	[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine	i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.5.1.46	NAD+	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)