Literature summary extracted from

Liao, D.I.; Wolff, E.C.; Park, M.H.; Davies, D.R.
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site (1998), Structure, 6(1), 23-32.

No PubMed abstract available

Crystallization (Commentary)

EC Number	Crystallization (Comment)	Organism
2.5.1.46	vapor diffusion in hanging drops, crystal structure of the enzyme-NAD complex at 2.2 A resolution	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.46	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.46	[eIF5A-precursor]-lysine + spermidine	-	Homo sapiens	[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine	i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine	?

Subunits

EC Number	Subunits	Comment	Organism
2.5.1.46	tetramer	four identical subunits arranged in 222 symmetry	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.5.1.46	NAD+	-	Homo sapiens

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Release 2023.1 (January 2023)