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Literature summary extracted from
- Quinolinate phosphoribosyltransferase: kinetic mechanism for a type II PRTase (2002), Biochemistry, 41, 3520-3528.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.19 | 5-phosphoribosyl-1-diphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium |  |
| 2.4.2.19 | nicotinate mononucleotide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 2.4.2.19 | Phthalic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.19 | 0.025 | - |
quinolinate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 2.4.2.19 | 0.03 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.19 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 2.4.2.19 | beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | predominantly ordered kinetic mechanism in which productive binding of quinolinate precedes that of 5-phospho-alpha-D-ribose 1-diphosphate | Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.19 | pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.19 | additional information | - |
additional information | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.4.2.19 | 0.044 | - |
Phthalate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 2.4.2.19 | 0.063 | - |
nicotinate mononucleotide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 2.4.2.19 | 2.2 | - |
5-phosphoribosyl-1-diphosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
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