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Literature summary extracted from

  • Taguchi, H.; Iwai, K.
    Inhibition of hog liver crystalline quinolinate phosphoribosyltransferase by nucleotides, quinolinate analogues and sulfhydryl reagents (1976), Agric. Biol. Chem., 40, 385-389.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.19 ADP 2 mM, 25% inhibition Sus scrofa
2.4.2.19 AMP 2 mM, 7% inhibition Sus scrofa
2.4.2.19 ATP 2 mM, 82% inhibition; inhibition is removed by raising Mg2+ concentrations Sus scrofa
2.4.2.19 CDP 2 mM, 20% inhibition Sus scrofa
2.4.2.19 CTP 2 mM, 77% inhibition Sus scrofa
2.4.2.19 dipicolinic acid 1 mM, 24% inhibition Sus scrofa
2.4.2.19 dithiobis(2-nitrobenzoic acid) 10 mM, 88.7% inhibition Sus scrofa
2.4.2.19 GDP 2 mM, 29% inhibition Sus scrofa
2.4.2.19 GTP 2 mM, 77% inhibition Sus scrofa
2.4.2.19 IDP 2 mM, 29% inhibition Sus scrofa
2.4.2.19 IMP 2 mM, 6% inhibition Sus scrofa
2.4.2.19 isocinchomeric acid 1 mM, 15% inhibition Sus scrofa
2.4.2.19 ITP 2 mM, 81% inhibition Sus scrofa
2.4.2.19 lutidinic acid 1 mM, 17% inhibition Sus scrofa
2.4.2.19 Monoiodoacetic acid 50 mM, 99.8% inhibition Sus scrofa
2.4.2.19 NEM 5 mM, 86% inhibition Sus scrofa
2.4.2.19 PCMB 0.05 mM, complete inhibition Sus scrofa
2.4.2.19 Phthalic acid competitive to quinolinate Sus scrofa
2.4.2.19 UDP 2 mM, 32% inhibition Sus scrofa
2.4.2.19 UTP 2 mM, 74% inhibition Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.19 Mg2+ absolute requirement. Optimal concentration is 1 mM in absence of ATP and 7 mM in presence of ATP at 5 mM Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.19 additional information Sus scrofa intermediary enzyme in the de novo NAD biosynthetic pathway ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.19 liver
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 additional information intermediary enzyme in the de novo NAD biosynthetic pathway Sus scrofa ?
-
?
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Sus scrofa nicotinate D-ribonucleotide + diphosphate + CO2
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.19 0.17
-
Phthalic acid
-
Sus scrofa