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Literature summary extracted from

  • Shibata, K.; Iwai, K.
    Effect of 5-phosphoribosyl-1-pyrophosphate on crystalline quinolinate phosphoribosyltransferase activities from hog kidney and hog liver (1980), Agric. Biol. Chem., 44, 2785-2791.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.2.19
-
Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.19 5-phosphoribosyl-1-diphosphate inhibition at alkaline pH and at physiological pH, pH 7.4, but not at an acidic pH, competitive for quinolinate. In presence of 30% glycerol, both the kidney and liver enzyme are inhibited, even at acidic pH Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.19 kidney
-
Sus scrofa
-
2.4.2.19 liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.19 0.0227 0.0919 enzyme from kidney Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Sus scrofa nicotinate D-ribonucleotide + diphosphate + CO2
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.19 5.5
-
in presence of 1 mM 5-phospho-alpha-D-ribose 1-diphosphate, enzyme from kidney Sus scrofa
2.4.2.19 6
-
in presence of 1 mM 5-phospho-alpha-D-ribose 1-diphosphate, enzyme from liver Sus scrofa
2.4.2.19 9
-
in presence of 0.4 mM 5-phospho-alpha-D-ribose 1-diphosphate, enzyme from kidney and liver Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.19 0.05
-
5-phosphoribosyl-1-diphosphate enzyme from liver Sus scrofa
2.4.2.19 0.8
-
5-phosphoribosyl-1-diphosphate enzyme from kidney Sus scrofa