Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Gholson, R.K.; Ueda, I.; Ogasawara, N.; Henderson, L.M.
    The enzymatic conversion of quinolinate to nicotinic acid mononucleotide in mammalian liver (1964), J. Biol. Chem., 239, 1208-1214.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.19 Tris
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.19 0.01
-
 nicotinic acid
-
 Bos taurus
2.4.2.19 0.05
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Bos taurus
2.4.2.19 0.06
-
 quinolinate
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.19 K+ monovalent cation required, K+, Li+ or NH4+ markedly stimulate Bos taurus
2.4.2.19 Li+ monovalent cation required, K+, Li+ or NH4+ markedly stimulate Bos taurus
2.4.2.19 Mg2+ maximal activity at 0.1-0.2 mM Bos taurus
2.4.2.19 Mn2+ half as effective as Mg2+ Bos taurus
2.4.2.19 NH4+ monovalent cation required, K+, Li+ or NH4+ markedly stimulate Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.19 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.19
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.19 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.19 0.073
-
-
 Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.19 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O
-
 Bos taurus beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?
2.4.2.19 pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Bos taurus nicotinate D-ribonucleotide + diphosphate + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.19 6.2
-
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.2.19 6.4 7.3 pH 6.4: about 50% of maximal activity, pH 7.3: about 55% of maximal activity Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.4.2.19 NAD+ 0.1 mM, 75% inhibition Bos taurus