BRENDA - Enzyme Database

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase

Banasik, M.; Komura, H.; Shimoyama, M.; Ueda, K.; J. Biol. Chem. 267, 1569-1575 (1992)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.4.2.30
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide
activates in presence of Mg2+, inhibits in absence of Mg2+
Bos taurus
2.4.2.30
harmaline hydrochloride
activates more strongly in absence of Mg2+ than in presence of Mg2+
Bos taurus
2.4.2.30
Phthalic acid
activates more strongly in absence of Mg2+ than in presence of Mg2+
Bos taurus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.30
1(2H)-phthalazinone
IC50: 0.012 mM
Bos taurus
2.4.2.30
1,2-benzopyrone
IC50: 2.8 mM
Bos taurus
2.4.2.30
1,3-benzodiazine
IC50: 2.0 mM
Bos taurus
2.4.2.30
1,3-dihydroxynaphthalene
IC50: 1.3 mM
Bos taurus
2.4.2.30
1,4-benzoquinone
IC50: 0.4 mM
Bos taurus
2.4.2.30
1,4-naphthalenedione
IC50: 0.25 mM
Bos taurus
2.4.2.30
1,5-dihydroxyisoquinoline
IC50: 0.00039 mM
Bos taurus
2.4.2.30
1,8-naphthalimide
IC50: 0.0014 mM
Bos taurus
2.4.2.30
1-hydroxy-2-methyl-4-aminonaphthalene
IC50: 1.3 mM
Bos taurus
2.4.2.30
1-hydroxyisoquinoline
IC50: 0.007 mM
Bos taurus
2.4.2.30
1-Indanone
IC50: 0.81 mM
Bos taurus
2.4.2.30
1-methylnicotinamide chloride
IC50: 3.8 mM
Bos taurus
2.4.2.30
2,3-benzodiazine
IC50: 0.15 mM
Bos taurus
2.4.2.30
2,3-dichloro-1,4-naphthoquinone
IC50: 0.26 mM
Bos taurus
2.4.2.30
2,3-dihydro-1,4-phthalazinedione
IC50: 0.03 mM
Bos taurus
2.4.2.30
2,4(1H,3H)-quinazolinedione
IC50: 0.0081 mM
Bos taurus
2.4.2.30
2,6-difluorobenzamide
IC50: 0.18 mM
Bos taurus
2.4.2.30
2-acetamidobenzamide
IC50: 1.0 mM
Bos taurus
2.4.2.30
2-amino-3-chloro-1,4-naphthoquinone
IC50: 0.82 mM
Bos taurus
2.4.2.30
2-Aminobenzamide
IC50: 0.65 mM
Bos taurus
2.4.2.30
2-bromobenzamide
IC50: 2.9 mM
Bos taurus
2.4.2.30
2-chlorobenzamide
IC50: 1.0 mM
Bos taurus
2.4.2.30
2-fluorobenzamide
IC50: 0.12 mM
Bos taurus
2.4.2.30
2-Hydroxy-1,4-naphthoquinone
IC50: 0.33 mM
Bos taurus
2.4.2.30
2-hydroxybenzamide
IC50: 0.82 mM
Bos taurus
2.4.2.30
2-mercapto-4(3H)-quinazolinone
IC50: 0.044 mM
Bos taurus
2.4.2.30
2-Methoxybenzamide
IC50: 0.2 mM
Bos taurus
2.4.2.30
2-methyl-1,4-benzopyrone
IC50: 0.045 mM
Bos taurus
2.4.2.30
2-methyl-1,4-naphthoquinone
IC50: 0.42 mM
Bos taurus
2.4.2.30
2-methyl-3-phytyl-1,4-naphthoquinone
IC50: 0.52 mM
Bos taurus
2.4.2.30
2-methyl-4(3H)-quinazolinone
IC50: 0.056 mM
Bos taurus
2.4.2.30
2-methylbenzamide
IC50: 1.5 mM
Bos taurus
2.4.2.30
2-methylchromone
IC50: 0.045 mM
Bos taurus
2.4.2.30
2-nitro-6(5H)-phenanthridione
IC50: 0.00035 mM
Bos taurus
2.4.2.30
2-phenylchromone
IC50: 0.022 mM
Bos taurus
2.4.2.30
2-trichloromethyl-4(3H)-quinazolinone
IC50: 2.2 mM
Bos taurus
2.4.2.30
2H-benz[c]isoquinolin-1-one
IC50: 0.0003 mM
Bos taurus
2.4.2.30
2H-benz[de]isoquinoline-1,3-dione
IC50: 0.0014 mM
Bos taurus
2.4.2.30
3,4-dihydro-1(2H)-naphthalenone
IC50: 0.31 mM
Bos taurus
2.4.2.30
3,5-dibromosalicylamide
IC50: 0.56 mM
Bos taurus
2.4.2.30
3,5-dimethoxybenzamide
IC50: 1.2 mM
Bos taurus
2.4.2.30
3,5-dinitrobenzamide
IC50: 2.5 mM
Bos taurus
2.4.2.30
3-(N,N-dimethylamino)benzamide
IC50: 0.12 mM
Bos taurus
2.4.2.30
3-Acetamidobenzamide
IC50: 0.012 mM
Bos taurus
2.4.2.30
3-acetamidosalicylamide
IC50: 2.0 mM
Bos taurus
2.4.2.30
3-aminobenzamide
IC50: 0.33 mM
Bos taurus
2.4.2.30
3-Aminophthalhydrazide
IC50: 0.023 mM
Bos taurus
2.4.2.30
3-bromobenzamide
IC50: 0.055 mM
Bos taurus
2.4.2.30
3-Chlorobenzamide
IC50: 0.22 mM
Bos taurus
2.4.2.30
3-Fluorobenzamide
IC50: 0.2 mM
Bos taurus
2.4.2.30
3-Hydroxybenzamide
IC50: 0.0091 mM
Bos taurus
2.4.2.30
3-Methoxybenzamide
IC50: 0.017 mM
Bos taurus
2.4.2.30
3-Methylbenzamide
IC50: 0.19 mM
Bos taurus
2.4.2.30
3-nitrobenzamide
IC50: 0.16 mM
Bos taurus
2.4.2.30
3-nitrophthalhydrazide
IC50: 0.072 mM
Bos taurus
2.4.2.30
3-nitrosalicylamide
IC50: 1.6 mM
Bos taurus
2.4.2.30
4,8-dihydroxy-2-quinolinecarboxylic acid
IC50: 0.19 mM
Bos taurus
2.4.2.30
4-amino-1,8-naphthalimide
IC50: 0.00018 mM
Bos taurus
2.4.2.30
4-Aminobenzamide
IC50: 1.8 mM
Bos taurus
2.4.2.30
4-aminophthalhydrazide
IC50: 0.29 mM
Bos taurus
2.4.2.30
4-bromobenzamide
IC50: 2.2 mM
Bos taurus
2.4.2.30
4-chlorobenzamide
IC50: 0.3 mM
Bos taurus
2.4.2.30
4-chromanone
IC50: 0.72 mM
Bos taurus
2.4.2.30
4-fluorobenzamide
IC50: 0.2 mM
Bos taurus
2.4.2.30
4-hydroxy-2-methylquinoline
IC50: 0.074 mM
Bos taurus
2.4.2.30
4-hydroxy-2-quinolinecarboxylic acid
IC50: 0.67 mM
Bos taurus
2.4.2.30
4-hydroxybenzamide
IC50: 0.28 mM
Bos taurus
2.4.2.30
4-Hydroxycoumarin
IC50: 0.57 mM
Bos taurus
2.4.2.30
4-hydroxypyridine
IC50: 2.3 mM
Bos taurus
2.4.2.30
4-hydroxyquinazoline
IC50: 0.0095 mM
Bos taurus
2.4.2.30
4-hydroxyquinoline
IC50: 0.08 mM
Bos taurus
2.4.2.30
4-methoxybenzamide
IC50: 1.1 mM
Bos taurus
2.4.2.30
4-methylbenzamide
IC50: 1.8 mM
Bos taurus
2.4.2.30
4-nitrophthalhydrazide
IC50: 0.51 mM
Bos taurus
2.4.2.30
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide
activates in presence of Mg2+, inhibits in absence of Mg2+
Bos taurus
2.4.2.30
5-acetamidosalicylamide
IC50: 0.045 mM
Bos taurus
2.4.2.30
5-aminosalicylamide
IC50: 0.1 mM
Bos taurus
2.4.2.30
5-Bromouracil
IC50: 0.16 mM
Bos taurus
2.4.2.30
5-Bromouridine
IC50: 0.21 mM
Bos taurus
2.4.2.30
5-chlorosalicylamide
IC50: 0.19 mM
Bos taurus
2.4.2.30
5-Chlorouracil
IC50: 0.27 mM
Bos taurus
2.4.2.30
5-hydroxy-1,4-naphthoquinone
IC50: 0.25 mM
Bos taurus
2.4.2.30
5-Hydroxy-2-methyl-1,4-naphthoquinone
IC50: 0.7 mM
Bos taurus
2.4.2.30
5-Iodouracil
IC50: 0.071 mM
Bos taurus
2.4.2.30
5-iodouridine
IC50: 0.043 mM
Bos taurus
2.4.2.30
5-Methylnicotinamide
IC50: 0.35 mM
Bos taurus
2.4.2.30
5-methyluracil
IC50: 0.29 mM
Bos taurus
2.4.2.30
5-Nitrouracil
IC50: 0.43 mM
Bos taurus
2.4.2.30
6(5H)-phenanthridinone
IC50: 0.0003 mM
Bos taurus
2.4.2.30
6-aminocoumarin
IC50: 0.85 mM
Bos taurus
2.4.2.30
6-aminonicotinamide
IC50: 1.1 mM
Bos taurus
2.4.2.30
8-acetamidocarsalam
IC50: 1.4 mM
Bos taurus
2.4.2.30
acetophenone
IC50: 2.3 mM
Bos taurus
2.4.2.30
all-trans-retinal
IC50: 0.45 mM
Bos taurus
2.4.2.30
alpha-picolinamide
IC50: 0.25 mM
Bos taurus
2.4.2.30
arachidonic acid
-
Bos taurus
2.4.2.30
Benzamide
IC50: 0.22 mM
Bos taurus
2.4.2.30
benzoyleneurea
IC50: 0.0081 mM
Bos taurus
2.4.2.30
carbonylsalicylamide
IC50: 0.46 mM
Bos taurus
2.4.2.30
carsalam
5 mM, 88% inhibition in presence of Mg2+, 68% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
Chlorthenoxazin
IC50: 0.0085 mM
Bos taurus
2.4.2.30
chromone-2-carboxylic acid
IC50: 0.56 mM
Bos taurus
2.4.2.30
cyclohexanecarboxamide
IC50: 0.62 mM
Bos taurus
2.4.2.30
EDTA
5 mM, 41% inhibition in presence of Mg2+, 2% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
flavone
IC50: 0.022 mM
Bos taurus
2.4.2.30
gamma-linolenic acid
IC50: 0.12 mM
Bos taurus
2.4.2.30
Isonicotinamide
IC50: 0.99 mM
Bos taurus
2.4.2.30
Isoquinoline
5 mM, 47% inhibition in presence of Mg2+, 34% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
linoleic acid
IC50: 0.048 mM
Bos taurus
2.4.2.30
linolenic acid
IC50: 0.11 mM
Bos taurus
2.4.2.30
m-acetamidoacetophenone
IC50: 0.93 mM
Bos taurus
2.4.2.30
m-aminoacetophenone
IC50: 1.9 mM
Bos taurus
2.4.2.30
m-hydroxyacetophenone
IC50: 0.6 mM
Bos taurus
2.4.2.30
m-phthalamide
IC50: 0.05 mM
Bos taurus
2.4.2.30
menadione sodium bisulfite
IC50: 0.72 mM
Bos taurus
2.4.2.30
N-(2-chloroethyl)1,8-naphthalamide
IC50: above 1.8 mM
Bos taurus
2.4.2.30
N-hydroxynaphthalimide sodium salt
IC50: 0.45 mM
Bos taurus
2.4.2.30
nicotinamide
IC50: 0.21 mM
Bos taurus
2.4.2.30
norharman
IC50: 4.7 mM
Bos taurus
2.4.2.30
novobiocin
IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
oleic acid
IC50: 0.082 mM
Bos taurus
2.4.2.30
palmitoleic acid
IC50: 0.095 mM
Bos taurus
2.4.2.30
phthalamide
IC50: 1.0 mM
Bos taurus
2.4.2.30
Phthalazine
5 mM, 91% inhibition in presence of Mg2+, 79% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
Quinazoline
5 mM, 63% inhibition in presence of Mg2+, 50% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
reserpine
IC50: 0.79 mM
Bos taurus
2.4.2.30
thiobenzamide
IC50: 0.62 mM
Bos taurus
2.4.2.30
Thionicotinamide
IC50: 1.8 mM
Bos taurus
2.4.2.30
thymidine
IC50: 0.18 mM
Bos taurus
2.4.2.30
trans-decahydro-1-naphthalenone
IC50: 4.3 mM
Bos taurus
2.4.2.30
vitamin K1
IC50: 0.0019 mM
Bos taurus
2.4.2.30
vitamin K3
IC50: 0.42 mM
Bos taurus
2.4.2.30
xanthurenic acid
5 mM, 88% inhibition in presence of Mg2+, 65% inhibition in absence of Mg2+
Bos taurus
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.2.30
Mg2+
activates
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.4.2.30
Bos taurus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.30
thymus
-
Bos taurus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.30
NAD+ + (ADP-D-ribosyl)n-acceptor
-
637997
Bos taurus
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.4.2.30
0.00018
-
IC50: 0.00018 mM
Bos taurus
4-amino-1,8-naphthalimide
2.4.2.30
0.0003
-
IC50: 0.0003 mM
Bos taurus
2H-benz[c]isoquinolin-1-one
2.4.2.30
0.0003
-
IC50: 0.0003 mM
Bos taurus
6(5H)-phenanthridinone
2.4.2.30
0.00035
-
IC50: 0.00035 mM
Bos taurus
2-nitro-6(5H)-phenanthridione
2.4.2.30
0.00039
-
IC50: 0.00039 mM
Bos taurus
1,5-dihydroxyisoquinoline
2.4.2.30
0.0014
-
IC50: 0.0014 mM
Bos taurus
1,8-naphthalimide
2.4.2.30
0.0014
-
IC50: 0.0014 mM
Bos taurus
2H-benz[de]isoquinoline-1,3-dione
2.4.2.30
0.0019
-
IC50: 0.0019 mM
Bos taurus
vitamin K1
2.4.2.30
0.007
-
IC50: 0.007 mM
Bos taurus
1-hydroxyisoquinoline
2.4.2.30
0.0081
-
IC50: 0.0081 mM
Bos taurus
2,4(1H,3H)-quinazolinedione
2.4.2.30
0.0081
-
IC50: 0.0081 mM
Bos taurus
benzoyleneurea
2.4.2.30
0.0085
-
IC50: 0.0085 mM
Bos taurus
Chlorthenoxazin
2.4.2.30
0.0091
-
IC50: 0.0091 mM
Bos taurus
3-Hydroxybenzamide
2.4.2.30
0.0095
-
IC50: 0.0095 mM
Bos taurus
4-hydroxyquinazoline
2.4.2.30
0.012
-
IC50: 0.012 mM
Bos taurus
1(2H)-phthalazinone
2.4.2.30
0.012
-
IC50: 0.012 mM
Bos taurus
3-Acetamidobenzamide
2.4.2.30
0.017
-
IC50: 0.017 mM
Bos taurus
3-Methoxybenzamide
2.4.2.30
0.022
-
IC50: 0.022 mM
Bos taurus
2-phenylchromone
2.4.2.30
0.022
-
IC50: 0.022 mM
Bos taurus
flavone
2.4.2.30
0.023
-
IC50: 0.023 mM
Bos taurus
3-Aminophthalhydrazide
2.4.2.30
0.03
-
IC50: 0.03 mM
Bos taurus
2,3-dihydro-1,4-phthalazinedione
2.4.2.30
0.043
-
IC50: 0.043 mM
Bos taurus
5-iodouridine
2.4.2.30
0.044
-
IC50: 0.044 mM
Bos taurus
2-mercapto-4(3H)-quinazolinone
2.4.2.30
0.045
-
IC50: 0.045 mM
Bos taurus
2-methyl-1,4-benzopyrone
2.4.2.30
0.045
-
IC50: 0.045 mM
Bos taurus
2-methylchromone
2.4.2.30
0.045
-
IC50: 0.045 mM
Bos taurus
5-acetamidosalicylamide
2.4.2.30
0.048
-
IC50: 0.048 mM
Bos taurus
linoleic acid
2.4.2.30
0.05
-
IC50: 0.05 mM
Bos taurus
m-phthalamide
2.4.2.30
0.055
-
IC50: 0.055 mM
Bos taurus
3-bromobenzamide
2.4.2.30
0.056
-
IC50: 0.056 mM
Bos taurus
2-methyl-4(3H)-quinazolinone
2.4.2.30
0.071
-
IC50: 0.071 mM
Bos taurus
5-Iodouracil
2.4.2.30
0.072
-
IC50: 0.072 mM
Bos taurus
3-nitrophthalhydrazide
2.4.2.30
0.074
-
IC50: 0.074 mM
Bos taurus
4-hydroxy-2-methylquinoline
2.4.2.30
0.08
-
IC50: 0.08 mM
Bos taurus
4-hydroxyquinoline
2.4.2.30
0.082
-
IC50: 0.082 mM
Bos taurus
oleic acid
2.4.2.30
0.095
-
IC50: 0.095 mM
Bos taurus
palmitoleic acid
2.4.2.30
0.1
-
IC50: 0.1 mM
Bos taurus
5-aminosalicylamide
2.4.2.30
0.11
-
IC50: 0.11 mM
Bos taurus
linolenic acid
2.4.2.30
0.12
-
IC50: 0.12 mM
Bos taurus
2-fluorobenzamide
2.4.2.30
0.12
-
IC50: 0.12 mM
Bos taurus
3-(N,N-dimethylamino)benzamide
2.4.2.30
0.12
-
IC50: 0.12 mM
Bos taurus
gamma-linolenic acid
2.4.2.30
0.15
-
IC50: 0.15 mM
Bos taurus
2,3-benzodiazine
2.4.2.30
0.16
-
IC50: 0.16 mM
Bos taurus
3-nitrobenzamide
2.4.2.30
0.16
-
IC50: 0.16 mM
Bos taurus
5-Bromouracil
2.4.2.30
0.18
-
IC50: 0.18 mM
Bos taurus
2,6-difluorobenzamide
2.4.2.30
0.18
-
IC50: 0.18 mM
Bos taurus
thymidine
2.4.2.30
0.19
-
IC50: 0.19 mM
Bos taurus
3-Methylbenzamide
2.4.2.30
0.19
-
IC50: 0.19 mM
Bos taurus
4,8-dihydroxy-2-quinolinecarboxylic acid
2.4.2.30
0.19
-
IC50: 0.19 mM
Bos taurus
5-chlorosalicylamide
2.4.2.30
0.2
-
IC50: 0.2 mM
Bos taurus
2-Methoxybenzamide
2.4.2.30
0.2
-
IC50: 0.2 mM
Bos taurus
3-Fluorobenzamide
2.4.2.30
0.2
-
IC50: 0.2 mM
Bos taurus
4-fluorobenzamide
2.4.2.30
0.21
-
IC50: 0.21 mM
Bos taurus
5-Bromouridine
2.4.2.30
0.21
-
IC50: 0.21 mM
Bos taurus
nicotinamide
2.4.2.30
0.22
-
IC50: 0.22 mM
Bos taurus
3-Chlorobenzamide
2.4.2.30
0.22
-
IC50: 0.22 mM
Bos taurus
Benzamide
2.4.2.30
0.25
-
IC50: 0.25 mM
Bos taurus
1,4-naphthalenedione
2.4.2.30
0.25
-
IC50: 0.25 mM
Bos taurus
5-hydroxy-1,4-naphthoquinone
2.4.2.30
0.25
-
IC50: 0.25 mM
Bos taurus
alpha-picolinamide
2.4.2.30
0.26
-
IC50: 0.26 mM
Bos taurus
2,3-dichloro-1,4-naphthoquinone
2.4.2.30
0.27
-
IC50: 0.27 mM
Bos taurus
5-Chlorouracil
2.4.2.30
0.28
-
IC50: 0.28 mM
Bos taurus
4-hydroxybenzamide
2.4.2.30
0.29
-
IC50: 0.29 mM
Bos taurus
4-aminophthalhydrazide
2.4.2.30
0.29
-
IC50: 0.29 mM
Bos taurus
5-methyluracil
2.4.2.30
0.3
-
IC50: 0.3 mM
Bos taurus
4-chlorobenzamide
2.4.2.30
0.31
-
IC50: 0.31 mM
Bos taurus
3,4-dihydro-1(2H)-naphthalenone
2.4.2.30
0.33
-
IC50: 0.33 mM
Bos taurus
2-Hydroxy-1,4-naphthoquinone
2.4.2.30
0.33
-
IC50: 0.33 mM
Bos taurus
3-aminobenzamide
2.4.2.30
0.35
-
IC50: 0.35 mM
Bos taurus
5-Methylnicotinamide
2.4.2.30
0.4
-
IC50: 0.4 mM
Bos taurus
1,4-benzoquinone
2.4.2.30
0.42
-
IC50: 0.42 mM
Bos taurus
2-methyl-1,4-naphthoquinone
2.4.2.30
0.42
-
IC50: 0.42 mM
Bos taurus
vitamin K3
2.4.2.30
0.43
-
IC50: 0.43 mM
Bos taurus
5-Nitrouracil
2.4.2.30
0.45
-
IC50: 0.45 mM
Bos taurus
all-trans-retinal
2.4.2.30
0.45
-
IC50: 0.45 mM
Bos taurus
N-hydroxynaphthalimide sodium salt
2.4.2.30
0.46
-
IC50: 0.46 mM
Bos taurus
carbonylsalicylamide
2.4.2.30
0.51
-
IC50: 0.51 mM
Bos taurus
4-nitrophthalhydrazide
2.4.2.30
0.52
-
IC50: 0.52 mM
Bos taurus
2-methyl-3-phytyl-1,4-naphthoquinone
2.4.2.30
0.56
-
IC50: 0.56 mM
Bos taurus
3,5-dibromosalicylamide
2.4.2.30
0.56
-
IC50: 0.56 mM
Bos taurus
chromone-2-carboxylic acid
2.4.2.30
0.57
-
IC50: 0.57 mM
Bos taurus
4-Hydroxycoumarin
2.4.2.30
0.6
-
IC50: 0.6 mM
Bos taurus
m-hydroxyacetophenone
2.4.2.30
0.62
-
IC50: 0.62 mM
Bos taurus
cyclohexanecarboxamide
2.4.2.30
0.62
-
IC50: 0.62 mM
Bos taurus
thiobenzamide
2.4.2.30
0.65
-
IC50: 0.65 mM
Bos taurus
2-Aminobenzamide
2.4.2.30
0.67
-
IC50: 0.67 mM
Bos taurus
4-hydroxy-2-quinolinecarboxylic acid
2.4.2.30
0.7
-
IC50: 0.7 mM
Bos taurus
5-Hydroxy-2-methyl-1,4-naphthoquinone
2.4.2.30
0.72
-
IC50: 0.72 mM
Bos taurus
4-chromanone
2.4.2.30
0.72
-
IC50: 0.72 mM
Bos taurus
menadione sodium bisulfite
2.4.2.30
0.79
-
IC50: 0.79 mM
Bos taurus
reserpine
2.4.2.30
0.81
-
IC50: 0.81 mM
Bos taurus
1-Indanone
2.4.2.30
0.82
-
IC50: 0.82 mM
Bos taurus
2-amino-3-chloro-1,4-naphthoquinone
2.4.2.30
0.82
-
IC50: 0.82 mM
Bos taurus
2-hydroxybenzamide
2.4.2.30
0.85
-
IC50: 0.85 mM
Bos taurus
6-aminocoumarin
2.4.2.30
0.93
-
IC50: 0.93 mM
Bos taurus
m-acetamidoacetophenone
2.4.2.30
0.99
-
IC50: 0.99 mM
Bos taurus
Isonicotinamide
2.4.2.30
1
-
IC50: 1.0 mM
Bos taurus
2-acetamidobenzamide
2.4.2.30
1
-
IC50: 1.0 mM
Bos taurus
2-chlorobenzamide
2.4.2.30
1
-
IC50: 1.0 mM
Bos taurus
phthalamide
2.4.2.30
1.1
-
IC50: 1.1 mM
Bos taurus
4-methoxybenzamide
2.4.2.30
1.1
-
IC50: 1.1 mM
Bos taurus
6-aminonicotinamide
2.4.2.30
1.2
-
IC50: 1.2 mM
Bos taurus
3,5-dimethoxybenzamide
2.4.2.30
1.3
-
IC50: 1.3 mM
Bos taurus
1,3-dihydroxynaphthalene
2.4.2.30
1.3
-
IC50: 1.3 mM
Bos taurus
1-hydroxy-2-methyl-4-aminonaphthalene
2.4.2.30
1.4
-
IC50: 1.4 mM
Bos taurus
8-acetamidocarsalam
2.4.2.30
1.5
-
IC50: 1.5 mM
Bos taurus
2-methylbenzamide
2.4.2.30
1.6
-
IC50: 1.6 mM
Bos taurus
3-nitrosalicylamide
2.4.2.30
1.8
-
IC50: 1.8 mM
Bos taurus
4-Aminobenzamide
2.4.2.30
1.8
-
IC50: 1.8 mM
Bos taurus
4-methylbenzamide
2.4.2.30
1.8
-
IC50: above 1.8 mM
Bos taurus
N-(2-chloroethyl)1,8-naphthalamide
2.4.2.30
1.8
-
IC50: 1.8 mM
Bos taurus
Thionicotinamide
2.4.2.30
1.9
-
IC50: 1.9 mM
Bos taurus
m-aminoacetophenone
2.4.2.30
2
-
IC50: 2.0 mM
Bos taurus
1,3-benzodiazine
2.4.2.30
2
-
IC50: 2.0 mM
Bos taurus
3-acetamidosalicylamide
2.4.2.30
2.2
-
IC50: 2.2 mM
Bos taurus
2-trichloromethyl-4(3H)-quinazolinone
2.4.2.30
2.2
-
IC50: 2.2 mM
Bos taurus
4-bromobenzamide
2.4.2.30
2.2
-
IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+
Bos taurus
novobiocin
2.4.2.30
2.3
-
IC50: 2.3 mM
Bos taurus
4-hydroxypyridine
2.4.2.30
2.3
-
IC50: 2.3 mM
Bos taurus
acetophenone
2.4.2.30
2.5
-
IC50: 2.5 mM
Bos taurus
3,5-dinitrobenzamide
2.4.2.30
2.8
-
IC50: 2.8 mM
Bos taurus
1,2-benzopyrone
2.4.2.30
2.9
-
IC50: 2.9 mM
Bos taurus
2-bromobenzamide
2.4.2.30
3.8
-
IC50: 3.8 mM
Bos taurus
1-methylnicotinamide chloride
2.4.2.30
4.3
-
IC50: 4.3 mM
Bos taurus
trans-decahydro-1-naphthalenone
2.4.2.30
4.7
-
IC50: 4.7 mM
Bos taurus
norharman
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.4.2.30
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide
activates in presence of Mg2+, inhibits in absence of Mg2+
Bos taurus
2.4.2.30
harmaline hydrochloride
activates more strongly in absence of Mg2+ than in presence of Mg2+
Bos taurus
2.4.2.30
Phthalic acid
activates more strongly in absence of Mg2+ than in presence of Mg2+
Bos taurus
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.4.2.30
0.00018
-
IC50: 0.00018 mM
Bos taurus
4-amino-1,8-naphthalimide
2.4.2.30
0.0003
-
IC50: 0.0003 mM
Bos taurus
2H-benz[c]isoquinolin-1-one
2.4.2.30
0.0003
-
IC50: 0.0003 mM
Bos taurus
6(5H)-phenanthridinone
2.4.2.30
0.00035
-
IC50: 0.00035 mM
Bos taurus
2-nitro-6(5H)-phenanthridione
2.4.2.30
0.00039
-
IC50: 0.00039 mM
Bos taurus
1,5-dihydroxyisoquinoline
2.4.2.30
0.0014
-
IC50: 0.0014 mM
Bos taurus
1,8-naphthalimide
2.4.2.30
0.0014
-
IC50: 0.0014 mM
Bos taurus
2H-benz[de]isoquinoline-1,3-dione
2.4.2.30
0.0019
-
IC50: 0.0019 mM
Bos taurus
vitamin K1
2.4.2.30
0.007
-
IC50: 0.007 mM
Bos taurus
1-hydroxyisoquinoline
2.4.2.30
0.0081
-
IC50: 0.0081 mM
Bos taurus
2,4(1H,3H)-quinazolinedione
2.4.2.30
0.0081
-
IC50: 0.0081 mM
Bos taurus
benzoyleneurea
2.4.2.30
0.0085
-
IC50: 0.0085 mM
Bos taurus
Chlorthenoxazin
2.4.2.30
0.0091
-
IC50: 0.0091 mM
Bos taurus
3-Hydroxybenzamide
2.4.2.30
0.0095
-
IC50: 0.0095 mM
Bos taurus
4-hydroxyquinazoline
2.4.2.30
0.012
-
IC50: 0.012 mM
Bos taurus
1(2H)-phthalazinone
2.4.2.30
0.012
-
IC50: 0.012 mM
Bos taurus
3-Acetamidobenzamide
2.4.2.30
0.017
-
IC50: 0.017 mM
Bos taurus
3-Methoxybenzamide
2.4.2.30
0.022
-
IC50: 0.022 mM
Bos taurus
2-phenylchromone
2.4.2.30
0.022
-
IC50: 0.022 mM
Bos taurus
flavone
2.4.2.30
0.023
-
IC50: 0.023 mM
Bos taurus
3-Aminophthalhydrazide
2.4.2.30
0.03
-
IC50: 0.03 mM
Bos taurus
2,3-dihydro-1,4-phthalazinedione
2.4.2.30
0.043
-
IC50: 0.043 mM
Bos taurus
5-iodouridine
2.4.2.30
0.044
-
IC50: 0.044 mM
Bos taurus
2-mercapto-4(3H)-quinazolinone
2.4.2.30
0.045
-
IC50: 0.045 mM
Bos taurus
2-methyl-1,4-benzopyrone
2.4.2.30
0.045
-
IC50: 0.045 mM
Bos taurus
2-methylchromone
2.4.2.30
0.045
-
IC50: 0.045 mM
Bos taurus
5-acetamidosalicylamide
2.4.2.30
0.048
-
IC50: 0.048 mM
Bos taurus
linoleic acid
2.4.2.30
0.05
-
IC50: 0.05 mM
Bos taurus
m-phthalamide
2.4.2.30
0.055
-
IC50: 0.055 mM
Bos taurus
3-bromobenzamide
2.4.2.30
0.056
-
IC50: 0.056 mM
Bos taurus
2-methyl-4(3H)-quinazolinone
2.4.2.30
0.071
-
IC50: 0.071 mM
Bos taurus
5-Iodouracil
2.4.2.30
0.072
-
IC50: 0.072 mM
Bos taurus
3-nitrophthalhydrazide
2.4.2.30
0.074
-
IC50: 0.074 mM
Bos taurus
4-hydroxy-2-methylquinoline
2.4.2.30
0.08
-
IC50: 0.08 mM
Bos taurus
4-hydroxyquinoline
2.4.2.30
0.082
-
IC50: 0.082 mM
Bos taurus
oleic acid
2.4.2.30
0.095
-
IC50: 0.095 mM
Bos taurus
palmitoleic acid
2.4.2.30
0.1
-
IC50: 0.1 mM
Bos taurus
5-aminosalicylamide
2.4.2.30
0.11
-
IC50: 0.11 mM
Bos taurus
linolenic acid
2.4.2.30
0.12
-
IC50: 0.12 mM
Bos taurus
2-fluorobenzamide
2.4.2.30
0.12
-
IC50: 0.12 mM
Bos taurus
3-(N,N-dimethylamino)benzamide
2.4.2.30
0.12
-
IC50: 0.12 mM
Bos taurus
gamma-linolenic acid
2.4.2.30
0.15
-
IC50: 0.15 mM
Bos taurus
2,3-benzodiazine
2.4.2.30
0.16
-
IC50: 0.16 mM
Bos taurus
3-nitrobenzamide
2.4.2.30
0.16
-
IC50: 0.16 mM
Bos taurus
5-Bromouracil
2.4.2.30
0.18
-
IC50: 0.18 mM
Bos taurus
2,6-difluorobenzamide
2.4.2.30
0.18
-
IC50: 0.18 mM
Bos taurus
thymidine
2.4.2.30
0.19
-
IC50: 0.19 mM
Bos taurus
3-Methylbenzamide
2.4.2.30
0.19
-
IC50: 0.19 mM
Bos taurus
4,8-dihydroxy-2-quinolinecarboxylic acid
2.4.2.30
0.19
-
IC50: 0.19 mM
Bos taurus
5-chlorosalicylamide
2.4.2.30
0.2
-
IC50: 0.2 mM
Bos taurus
2-Methoxybenzamide
2.4.2.30
0.2
-
IC50: 0.2 mM
Bos taurus
3-Fluorobenzamide
2.4.2.30
0.2
-
IC50: 0.2 mM
Bos taurus
4-fluorobenzamide
2.4.2.30
0.21
-
IC50: 0.21 mM
Bos taurus
5-Bromouridine
2.4.2.30
0.21
-
IC50: 0.21 mM
Bos taurus
nicotinamide
2.4.2.30
0.22
-
IC50: 0.22 mM
Bos taurus
3-Chlorobenzamide
2.4.2.30
0.22
-
IC50: 0.22 mM
Bos taurus
Benzamide
2.4.2.30
0.25
-
IC50: 0.25 mM
Bos taurus
1,4-naphthalenedione
2.4.2.30
0.25
-
IC50: 0.25 mM
Bos taurus
5-hydroxy-1,4-naphthoquinone
2.4.2.30
0.25
-
IC50: 0.25 mM
Bos taurus
alpha-picolinamide
2.4.2.30
0.26
-
IC50: 0.26 mM
Bos taurus
2,3-dichloro-1,4-naphthoquinone
2.4.2.30
0.27
-
IC50: 0.27 mM
Bos taurus
5-Chlorouracil
2.4.2.30
0.28
-
IC50: 0.28 mM
Bos taurus
4-hydroxybenzamide
2.4.2.30
0.29
-
IC50: 0.29 mM
Bos taurus
4-aminophthalhydrazide
2.4.2.30
0.29
-
IC50: 0.29 mM
Bos taurus
5-methyluracil
2.4.2.30
0.3
-
IC50: 0.3 mM
Bos taurus
4-chlorobenzamide
2.4.2.30
0.31
-
IC50: 0.31 mM
Bos taurus
3,4-dihydro-1(2H)-naphthalenone
2.4.2.30
0.33
-
IC50: 0.33 mM
Bos taurus
2-Hydroxy-1,4-naphthoquinone
2.4.2.30
0.33
-
IC50: 0.33 mM
Bos taurus
3-aminobenzamide
2.4.2.30
0.35
-
IC50: 0.35 mM
Bos taurus
5-Methylnicotinamide
2.4.2.30
0.4
-
IC50: 0.4 mM
Bos taurus
1,4-benzoquinone
2.4.2.30
0.42
-
IC50: 0.42 mM
Bos taurus
2-methyl-1,4-naphthoquinone
2.4.2.30
0.42
-
IC50: 0.42 mM
Bos taurus
vitamin K3
2.4.2.30
0.43
-
IC50: 0.43 mM
Bos taurus
5-Nitrouracil
2.4.2.30
0.45
-
IC50: 0.45 mM
Bos taurus
all-trans-retinal
2.4.2.30
0.45
-
IC50: 0.45 mM
Bos taurus
N-hydroxynaphthalimide sodium salt
2.4.2.30
0.46
-
IC50: 0.46 mM
Bos taurus
carbonylsalicylamide
2.4.2.30
0.51
-
IC50: 0.51 mM
Bos taurus
4-nitrophthalhydrazide
2.4.2.30
0.52
-
IC50: 0.52 mM
Bos taurus
2-methyl-3-phytyl-1,4-naphthoquinone
2.4.2.30
0.56
-
IC50: 0.56 mM
Bos taurus
3,5-dibromosalicylamide
2.4.2.30
0.56
-
IC50: 0.56 mM
Bos taurus
chromone-2-carboxylic acid
2.4.2.30
0.57
-
IC50: 0.57 mM
Bos taurus
4-Hydroxycoumarin
2.4.2.30
0.6
-
IC50: 0.6 mM
Bos taurus
m-hydroxyacetophenone
2.4.2.30
0.62
-
IC50: 0.62 mM
Bos taurus
cyclohexanecarboxamide
2.4.2.30
0.62
-
IC50: 0.62 mM
Bos taurus
thiobenzamide
2.4.2.30
0.65
-
IC50: 0.65 mM
Bos taurus
2-Aminobenzamide
2.4.2.30
0.67
-
IC50: 0.67 mM
Bos taurus
4-hydroxy-2-quinolinecarboxylic acid
2.4.2.30
0.7
-
IC50: 0.7 mM
Bos taurus
5-Hydroxy-2-methyl-1,4-naphthoquinone
2.4.2.30
0.72
-
IC50: 0.72 mM
Bos taurus
4-chromanone
2.4.2.30
0.72
-
IC50: 0.72 mM
Bos taurus
menadione sodium bisulfite
2.4.2.30
0.79
-
IC50: 0.79 mM
Bos taurus
reserpine
2.4.2.30
0.81
-
IC50: 0.81 mM
Bos taurus
1-Indanone
2.4.2.30
0.82
-
IC50: 0.82 mM
Bos taurus
2-amino-3-chloro-1,4-naphthoquinone
2.4.2.30
0.82
-
IC50: 0.82 mM
Bos taurus
2-hydroxybenzamide
2.4.2.30
0.85
-
IC50: 0.85 mM
Bos taurus
6-aminocoumarin
2.4.2.30
0.93
-
IC50: 0.93 mM
Bos taurus
m-acetamidoacetophenone
2.4.2.30
0.99
-
IC50: 0.99 mM
Bos taurus
Isonicotinamide
2.4.2.30
1
-
IC50: 1.0 mM
Bos taurus
2-acetamidobenzamide
2.4.2.30
1
-
IC50: 1.0 mM
Bos taurus
2-chlorobenzamide
2.4.2.30
1
-
IC50: 1.0 mM
Bos taurus
phthalamide
2.4.2.30
1.1
-
IC50: 1.1 mM
Bos taurus
4-methoxybenzamide
2.4.2.30
1.1
-
IC50: 1.1 mM
Bos taurus
6-aminonicotinamide
2.4.2.30
1.2
-
IC50: 1.2 mM
Bos taurus
3,5-dimethoxybenzamide
2.4.2.30
1.3
-
IC50: 1.3 mM
Bos taurus
1,3-dihydroxynaphthalene
2.4.2.30
1.3
-
IC50: 1.3 mM
Bos taurus
1-hydroxy-2-methyl-4-aminonaphthalene
2.4.2.30
1.4
-
IC50: 1.4 mM
Bos taurus
8-acetamidocarsalam
2.4.2.30
1.5
-
IC50: 1.5 mM
Bos taurus
2-methylbenzamide
2.4.2.30
1.6
-
IC50: 1.6 mM
Bos taurus
3-nitrosalicylamide
2.4.2.30
1.8
-
IC50: 1.8 mM
Bos taurus
4-Aminobenzamide
2.4.2.30
1.8
-
IC50: 1.8 mM
Bos taurus
4-methylbenzamide
2.4.2.30
1.8
-
IC50: above 1.8 mM
Bos taurus
N-(2-chloroethyl)1,8-naphthalamide
2.4.2.30
1.8
-
IC50: 1.8 mM
Bos taurus
Thionicotinamide
2.4.2.30
1.9
-
IC50: 1.9 mM
Bos taurus
m-aminoacetophenone
2.4.2.30
2
-
IC50: 2.0 mM
Bos taurus
1,3-benzodiazine
2.4.2.30
2
-
IC50: 2.0 mM
Bos taurus
3-acetamidosalicylamide
2.4.2.30
2.2
-
IC50: 2.2 mM
Bos taurus
2-trichloromethyl-4(3H)-quinazolinone
2.4.2.30
2.2
-
IC50: 2.2 mM
Bos taurus
4-bromobenzamide
2.4.2.30
2.2
-
IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+
Bos taurus
novobiocin
2.4.2.30
2.3
-
IC50: 2.3 mM
Bos taurus
4-hydroxypyridine
2.4.2.30
2.3
-
IC50: 2.3 mM
Bos taurus
acetophenone
2.4.2.30
2.5
-
IC50: 2.5 mM
Bos taurus
3,5-dinitrobenzamide
2.4.2.30
2.8
-
IC50: 2.8 mM
Bos taurus
1,2-benzopyrone
2.4.2.30
2.9
-
IC50: 2.9 mM
Bos taurus
2-bromobenzamide
2.4.2.30
3.8
-
IC50: 3.8 mM
Bos taurus
1-methylnicotinamide chloride
2.4.2.30
4.3
-
IC50: 4.3 mM
Bos taurus
trans-decahydro-1-naphthalenone
2.4.2.30
4.7
-
IC50: 4.7 mM
Bos taurus
norharman
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.4.2.30
1(2H)-phthalazinone
IC50: 0.012 mM
Bos taurus
2.4.2.30
1,2-benzopyrone
IC50: 2.8 mM
Bos taurus
2.4.2.30
1,3-benzodiazine
IC50: 2.0 mM
Bos taurus
2.4.2.30
1,3-dihydroxynaphthalene
IC50: 1.3 mM
Bos taurus
2.4.2.30
1,4-benzoquinone
IC50: 0.4 mM
Bos taurus
2.4.2.30
1,4-naphthalenedione
IC50: 0.25 mM
Bos taurus
2.4.2.30
1,5-dihydroxyisoquinoline
IC50: 0.00039 mM
Bos taurus
2.4.2.30
1,8-naphthalimide
IC50: 0.0014 mM
Bos taurus
2.4.2.30
1-hydroxy-2-methyl-4-aminonaphthalene
IC50: 1.3 mM
Bos taurus
2.4.2.30
1-hydroxyisoquinoline
IC50: 0.007 mM
Bos taurus
2.4.2.30
1-Indanone
IC50: 0.81 mM
Bos taurus
2.4.2.30
1-methylnicotinamide chloride
IC50: 3.8 mM
Bos taurus
2.4.2.30
2,3-benzodiazine
IC50: 0.15 mM
Bos taurus
2.4.2.30
2,3-dichloro-1,4-naphthoquinone
IC50: 0.26 mM
Bos taurus
2.4.2.30
2,3-dihydro-1,4-phthalazinedione
IC50: 0.03 mM
Bos taurus
2.4.2.30
2,4(1H,3H)-quinazolinedione
IC50: 0.0081 mM
Bos taurus
2.4.2.30
2,6-difluorobenzamide
IC50: 0.18 mM
Bos taurus
2.4.2.30
2-acetamidobenzamide
IC50: 1.0 mM
Bos taurus
2.4.2.30
2-amino-3-chloro-1,4-naphthoquinone
IC50: 0.82 mM
Bos taurus
2.4.2.30
2-Aminobenzamide
IC50: 0.65 mM
Bos taurus
2.4.2.30
2-bromobenzamide
IC50: 2.9 mM
Bos taurus
2.4.2.30
2-chlorobenzamide
IC50: 1.0 mM
Bos taurus
2.4.2.30
2-fluorobenzamide
IC50: 0.12 mM
Bos taurus
2.4.2.30
2-Hydroxy-1,4-naphthoquinone
IC50: 0.33 mM
Bos taurus
2.4.2.30
2-hydroxybenzamide
IC50: 0.82 mM
Bos taurus
2.4.2.30
2-mercapto-4(3H)-quinazolinone
IC50: 0.044 mM
Bos taurus
2.4.2.30
2-Methoxybenzamide
IC50: 0.2 mM
Bos taurus
2.4.2.30
2-methyl-1,4-benzopyrone
IC50: 0.045 mM
Bos taurus
2.4.2.30
2-methyl-1,4-naphthoquinone
IC50: 0.42 mM
Bos taurus
2.4.2.30
2-methyl-3-phytyl-1,4-naphthoquinone
IC50: 0.52 mM
Bos taurus
2.4.2.30
2-methyl-4(3H)-quinazolinone
IC50: 0.056 mM
Bos taurus
2.4.2.30
2-methylbenzamide
IC50: 1.5 mM
Bos taurus
2.4.2.30
2-methylchromone
IC50: 0.045 mM
Bos taurus
2.4.2.30
2-nitro-6(5H)-phenanthridione
IC50: 0.00035 mM
Bos taurus
2.4.2.30
2-phenylchromone
IC50: 0.022 mM
Bos taurus
2.4.2.30
2-trichloromethyl-4(3H)-quinazolinone
IC50: 2.2 mM
Bos taurus
2.4.2.30
2H-benz[c]isoquinolin-1-one
IC50: 0.0003 mM
Bos taurus
2.4.2.30
2H-benz[de]isoquinoline-1,3-dione
IC50: 0.0014 mM
Bos taurus
2.4.2.30
3,4-dihydro-1(2H)-naphthalenone
IC50: 0.31 mM
Bos taurus
2.4.2.30
3,5-dibromosalicylamide
IC50: 0.56 mM
Bos taurus
2.4.2.30
3,5-dimethoxybenzamide
IC50: 1.2 mM
Bos taurus
2.4.2.30
3,5-dinitrobenzamide
IC50: 2.5 mM
Bos taurus
2.4.2.30
3-(N,N-dimethylamino)benzamide
IC50: 0.12 mM
Bos taurus
2.4.2.30
3-Acetamidobenzamide
IC50: 0.012 mM
Bos taurus
2.4.2.30
3-acetamidosalicylamide
IC50: 2.0 mM
Bos taurus
2.4.2.30
3-aminobenzamide
IC50: 0.33 mM
Bos taurus
2.4.2.30
3-Aminophthalhydrazide
IC50: 0.023 mM
Bos taurus
2.4.2.30
3-bromobenzamide
IC50: 0.055 mM
Bos taurus
2.4.2.30
3-Chlorobenzamide
IC50: 0.22 mM
Bos taurus
2.4.2.30
3-Fluorobenzamide
IC50: 0.2 mM
Bos taurus
2.4.2.30
3-Hydroxybenzamide
IC50: 0.0091 mM
Bos taurus
2.4.2.30
3-Methoxybenzamide
IC50: 0.017 mM
Bos taurus
2.4.2.30
3-Methylbenzamide
IC50: 0.19 mM
Bos taurus
2.4.2.30
3-nitrobenzamide
IC50: 0.16 mM
Bos taurus
2.4.2.30
3-nitrophthalhydrazide
IC50: 0.072 mM
Bos taurus
2.4.2.30
3-nitrosalicylamide
IC50: 1.6 mM
Bos taurus
2.4.2.30
4,8-dihydroxy-2-quinolinecarboxylic acid
IC50: 0.19 mM
Bos taurus
2.4.2.30
4-amino-1,8-naphthalimide
IC50: 0.00018 mM
Bos taurus
2.4.2.30
4-Aminobenzamide
IC50: 1.8 mM
Bos taurus
2.4.2.30
4-aminophthalhydrazide
IC50: 0.29 mM
Bos taurus
2.4.2.30
4-bromobenzamide
IC50: 2.2 mM
Bos taurus
2.4.2.30
4-chlorobenzamide
IC50: 0.3 mM
Bos taurus
2.4.2.30
4-chromanone
IC50: 0.72 mM
Bos taurus
2.4.2.30
4-fluorobenzamide
IC50: 0.2 mM
Bos taurus
2.4.2.30
4-hydroxy-2-methylquinoline
IC50: 0.074 mM
Bos taurus
2.4.2.30
4-hydroxy-2-quinolinecarboxylic acid
IC50: 0.67 mM
Bos taurus
2.4.2.30
4-hydroxybenzamide
IC50: 0.28 mM
Bos taurus
2.4.2.30
4-Hydroxycoumarin
IC50: 0.57 mM
Bos taurus
2.4.2.30
4-hydroxypyridine
IC50: 2.3 mM
Bos taurus
2.4.2.30
4-hydroxyquinazoline
IC50: 0.0095 mM
Bos taurus
2.4.2.30
4-hydroxyquinoline
IC50: 0.08 mM
Bos taurus
2.4.2.30
4-methoxybenzamide
IC50: 1.1 mM
Bos taurus
2.4.2.30
4-methylbenzamide
IC50: 1.8 mM
Bos taurus
2.4.2.30
4-nitrophthalhydrazide
IC50: 0.51 mM
Bos taurus
2.4.2.30
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide
activates in presence of Mg2+, inhibits in absence of Mg2+
Bos taurus
2.4.2.30
5-acetamidosalicylamide
IC50: 0.045 mM
Bos taurus
2.4.2.30
5-aminosalicylamide
IC50: 0.1 mM
Bos taurus
2.4.2.30
5-Bromouracil
IC50: 0.16 mM
Bos taurus
2.4.2.30
5-Bromouridine
IC50: 0.21 mM
Bos taurus
2.4.2.30
5-chlorosalicylamide
IC50: 0.19 mM
Bos taurus
2.4.2.30
5-Chlorouracil
IC50: 0.27 mM
Bos taurus
2.4.2.30
5-hydroxy-1,4-naphthoquinone
IC50: 0.25 mM
Bos taurus
2.4.2.30
5-Hydroxy-2-methyl-1,4-naphthoquinone
IC50: 0.7 mM
Bos taurus
2.4.2.30
5-Iodouracil
IC50: 0.071 mM
Bos taurus
2.4.2.30
5-iodouridine
IC50: 0.043 mM
Bos taurus
2.4.2.30
5-Methylnicotinamide
IC50: 0.35 mM
Bos taurus
2.4.2.30
5-methyluracil
IC50: 0.29 mM
Bos taurus
2.4.2.30
5-Nitrouracil
IC50: 0.43 mM
Bos taurus
2.4.2.30
6(5H)-phenanthridinone
IC50: 0.0003 mM
Bos taurus
2.4.2.30
6-aminocoumarin
IC50: 0.85 mM
Bos taurus
2.4.2.30
6-aminonicotinamide
IC50: 1.1 mM
Bos taurus
2.4.2.30
8-acetamidocarsalam
IC50: 1.4 mM
Bos taurus
2.4.2.30
acetophenone
IC50: 2.3 mM
Bos taurus
2.4.2.30
all-trans-retinal
IC50: 0.45 mM
Bos taurus
2.4.2.30
alpha-picolinamide
IC50: 0.25 mM
Bos taurus
2.4.2.30
arachidonic acid
-
Bos taurus
2.4.2.30
Benzamide
IC50: 0.22 mM
Bos taurus
2.4.2.30
benzoyleneurea
IC50: 0.0081 mM
Bos taurus
2.4.2.30
carbonylsalicylamide
IC50: 0.46 mM
Bos taurus
2.4.2.30
carsalam
5 mM, 88% inhibition in presence of Mg2+, 68% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
Chlorthenoxazin
IC50: 0.0085 mM
Bos taurus
2.4.2.30
chromone-2-carboxylic acid
IC50: 0.56 mM
Bos taurus
2.4.2.30
cyclohexanecarboxamide
IC50: 0.62 mM
Bos taurus
2.4.2.30
EDTA
5 mM, 41% inhibition in presence of Mg2+, 2% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
flavone
IC50: 0.022 mM
Bos taurus
2.4.2.30
gamma-linolenic acid
IC50: 0.12 mM
Bos taurus
2.4.2.30
Isonicotinamide
IC50: 0.99 mM
Bos taurus
2.4.2.30
Isoquinoline
5 mM, 47% inhibition in presence of Mg2+, 34% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
linoleic acid
IC50: 0.048 mM
Bos taurus
2.4.2.30
linolenic acid
IC50: 0.11 mM
Bos taurus
2.4.2.30
m-acetamidoacetophenone
IC50: 0.93 mM
Bos taurus
2.4.2.30
m-aminoacetophenone
IC50: 1.9 mM
Bos taurus
2.4.2.30
m-hydroxyacetophenone
IC50: 0.6 mM
Bos taurus
2.4.2.30
m-phthalamide
IC50: 0.05 mM
Bos taurus
2.4.2.30
menadione sodium bisulfite
IC50: 0.72 mM
Bos taurus
2.4.2.30
N-(2-chloroethyl)1,8-naphthalamide
IC50: above 1.8 mM
Bos taurus
2.4.2.30
N-hydroxynaphthalimide sodium salt
IC50: 0.45 mM
Bos taurus
2.4.2.30
nicotinamide
IC50: 0.21 mM
Bos taurus
2.4.2.30
norharman
IC50: 4.7 mM
Bos taurus
2.4.2.30
novobiocin
IC50: 2.2 mM, 5 mM, 90% inhibition in presence of Mg2+, 59% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
oleic acid
IC50: 0.082 mM
Bos taurus
2.4.2.30
palmitoleic acid
IC50: 0.095 mM
Bos taurus
2.4.2.30
phthalamide
IC50: 1.0 mM
Bos taurus
2.4.2.30
Phthalazine
5 mM, 91% inhibition in presence of Mg2+, 79% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
Quinazoline
5 mM, 63% inhibition in presence of Mg2+, 50% inhibition in absence of Mg2+
Bos taurus
2.4.2.30
reserpine
IC50: 0.79 mM
Bos taurus
2.4.2.30
thiobenzamide
IC50: 0.62 mM
Bos taurus
2.4.2.30
Thionicotinamide
IC50: 1.8 mM
Bos taurus
2.4.2.30
thymidine
IC50: 0.18 mM
Bos taurus
2.4.2.30
trans-decahydro-1-naphthalenone
IC50: 4.3 mM
Bos taurus
2.4.2.30
vitamin K1
IC50: 0.0019 mM
Bos taurus
2.4.2.30
vitamin K3
IC50: 0.42 mM
Bos taurus
2.4.2.30
xanthurenic acid
5 mM, 88% inhibition in presence of Mg2+, 65% inhibition in absence of Mg2+
Bos taurus
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.4.2.30
Mg2+
activates
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.4.2.30
thymus
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.4.2.30
NAD+ + (ADP-D-ribosyl)n-acceptor
-
637997
Bos taurus
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
-
-
?