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Literature summary extracted from

  • Jakoby, W.B.; Keen, J.H.
    A triple-threat in detoxification: the glutathione S-transferases (1977), Trends Biochem. Sci., 2, 229-231.
No PubMed abstract available

General Stability

EC Number General Stability Organism
2.5.1.18 guanidine hydrochloride, 6 M, denaturation Homo sapiens
2.5.1.18 guanidine hydrochloride, 6 M, denaturation Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 45000
-
-
 Homo sapiens
2.5.1.18 45000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.18 RX + glutathione Homo sapiens participates in detoxification HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione Rattus norvegicus participates in detoxification HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione Homo sapiens first step in mercapturic acid synthesis HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione Rattus norvegicus first step in mercapturic acid synthesis HX + R-S-glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Homo sapiens
-
-
-
2.5.1.18 Pisum sativum
-
 pea
-
2.5.1.18 Rattus norvegicus
-
-
-
2.5.1.18 Zea mays
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18
-
 Homo sapiens
2.5.1.18
-
 Rattus norvegicus
2.5.1.18
-
 Zea mays

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.18 RX + glutathione = HX + R-S-glutathione mechanism Homo sapiens
a
2.5.1.18 RX + glutathione = HX + R-S-glutathione mechanism Rattus norvegicus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
 Rattus norvegicus ?
-
 ?
2.5.1.18 glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
-
 Rattus norvegicus ?
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Pisum sativum S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Zea mays S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + ethacrynic acid
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + ethacrynic acid
-
 Rattus norvegicus ?
-
 ?
2.5.1.18 glutathione + iodomethane
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + iodomethane
-
 Rattus norvegicus ?
-
 ?
2.5.1.18 additional information catalyzes the reaction of glutathione with a large number of compounds bearing an electrophilic carbon to form the corresponding thioether Homo sapiens ?
-
 ?
2.5.1.18 additional information catalyzes the reaction of glutathione with a large number of compounds bearing an electrophilic carbon to form the corresponding thioether Rattus norvegicus ?
-
 ?
2.5.1.18 additional information isomerization of DELTA5- to DELTA4- unsaturated 3-keto steroids Homo sapiens ?
-
 ?
2.5.1.18 additional information isomerization of DELTA5- to DELTA4- unsaturated 3-keto steroids Rattus norvegicus ?
-
 ?
2.5.1.18 RSSR + glutathione
-
 Homo sapiens glutathione-SSR + R-SH
-
 ?
2.5.1.18 RSSR + glutathione
-
 Rattus norvegicus glutathione-SSR + R-SH
-
 ?
2.5.1.18 RX + glutathione participates in detoxification Homo sapiens HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione participates in detoxification Rattus norvegicus HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione first step in mercapturic acid synthesis Homo sapiens HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione first step in mercapturic acid synthesis Rattus norvegicus HX + R-S-glutathione
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.18 dimer
-
 Homo sapiens
2.5.1.18 dimer
-
 Rattus norvegicus
2.5.1.18 dimer
-
 Pisum sativum
2.5.1.18 dimer
-
 Zea mays