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Literature summary extracted from

  • Habig, W.H.; Jakoby, W.B.
    Glutathione S-transferases (rat and human) (1981), Methods Enzymol., 77, 218-231.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 45000 49000
-
 Homo sapiens
2.5.1.18 45000 49000
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.18 RX + glutathione Homo sapiens first step in mercapturic acid synthesis HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione Rattus norvegicus first step in mercapturic acid synthesis HX + R-S-glutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Homo sapiens
-
-
-
2.5.1.18 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18 forms: alpha, beta, gamma, delta, epsilon and a species with a very low isoelectric point Homo sapiens
2.5.1.18 isoenzyme A, AA, B, C and E Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 erythrocyte
-
 Homo sapiens
-
2.5.1.18 liver
-
 Homo sapiens
-
2.5.1.18 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.18 0.81
-
 isoenzyme B Rattus norvegicus
2.5.1.18 2
-
 isoenzyme C Rattus norvegicus
2.5.1.18 4.1
-
 isoenzyme A Rattus norvegicus
2.5.1.18 14
-
 isoenzyme AA Rattus norvegicus
2.5.1.18 16
-
 isoenzyme beta Homo sapiens
2.5.1.18 17
-
 isoenzyme gamma Homo sapiens
2.5.1.18 29.2
-
 isoenzyme E Rattus norvegicus
2.5.1.18 34
-
 isoenzyme epsilon Homo sapiens
2.5.1.18 37
-
 isoenzyme delta Homo sapiens
2.5.1.18 66
-
 species with very low isoelectric point from erythrocytes Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.5.1.18 -70°C, stable for several months Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
 Homo sapiens ?
-
 ?
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene
-
 Rattus norvegicus ?
-
 ?
2.5.1.18 glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane isoenzyme E Rattus norvegicus ?
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 additional information any compound bearing a sufficiently electrophilic atom may be attacked, reactions with C,S,N and O atoms are possible Homo sapiens ?
-
 ?
2.5.1.18 additional information any compound bearing a sufficiently electrophilic atom may be attacked, reactions with C,S,N and O atoms are possible Rattus norvegicus ?
-
 ?
2.5.1.18 RX + glutathione first step in mercapturic acid synthesis Homo sapiens HX + R-S-glutathione
-
 ?
2.5.1.18 RX + glutathione first step in mercapturic acid synthesis Rattus norvegicus HX + R-S-glutathione
-
 ?