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Literature summary extracted from

  • Warholm, M.; Jensson, H.; Tahir, M.K.; Mannervik, B.
    Purification and characterization of three distinct glutathione transferases from mouse liver (1986), Biochemistry, 25, 4119-4125.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.18 N-ethylmaleimide
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.18 bromosulfophthalein
-
 Mus musculus
2.5.1.18 Cibacron blue
-
 Mus musculus
2.5.1.18 Hematin
-
 Mus musculus
2.5.1.18 additional information difference in sensitivity to inhibition of enzyme MI, MII and MIII Mus musculus
2.5.1.18 S-(4-Bromobenzyl)glutathione
-
 Mus musculus
2.5.1.18 S-hexylglutathione
-
 Mus musculus
2.5.1.18 sulfophthalein
-
 Mus musculus
2.5.1.18 Tributyltin acetate
-
 Mus musculus
2.5.1.18 Triethyltin bromide
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.18 cytosol
-
 Mus musculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.18 23000
-
 2 * 23000, enzyme MII, SDS-PAGE Mus musculus
2.5.1.18 25000
-
 2 * 25000, enzyme MI, SDS-PAGE Mus musculus
2.5.1.18 26500
-
 2 * 26500, enzyme MIII, SDS-PAGE Mus musculus
2.5.1.18 45000
-
 gel filtration Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.18 Mus musculus
-
 3 forms, products of different genes: MI, MII, MIII
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.18
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.18 liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.18 148
-
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.18 glutathione + 1,2-dichloro-4-nitrobenzene enzyme MIII Mus musculus ?
-
 ?
2.5.1.18 glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
-
 Mus musculus ?
-
 ?
2.5.1.18 glutathione + 1-chloro-2,4-dinitrobenzene
-
 Mus musculus S-2,4-dinitrophenylglutathione + HCl
-
 ?
2.5.1.18 glutathione + 4-hydroxydecenal
-
 Mus musculus ?
-
 ?
2.5.1.18 glutathione + 4-hydroxynonenal
-
 Mus musculus ?
-
 ?
2.5.1.18 glutathione + cumene hydroperoxide isozyme MI Mus musculus ?
-
 ?
2.5.1.18 additional information specificity Mus musculus ?
-
 ?
2.5.1.18 RX + glutathione RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange Mus musculus HX + R-S-glutathione
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.18 dimer 2 * 23000, enzyme MII, SDS-PAGE Mus musculus
2.5.1.18 dimer 2 * 25000, enzyme MI, SDS-PAGE Mus musculus
2.5.1.18 dimer 2 * 26500, enzyme MIII, SDS-PAGE Mus musculus