EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.4.21 | 0.02 | - |
5-phospho-alpha-D-ribose 1-diphosphate | in the coupled reaction, 200fold lower than in the uncoupled reaction | Salmonella enterica subsp. enterica serovar Typhimurium | |
6.3.4.21 | 0.33 | - |
ATP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
6.3.4.21 | 1.16 | - |
ITP | good alternative substrate for ATP | Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.4.21 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | the enzyme is a facultative ATPase that uses ATP hydrolysis to drive the synthesis of nicotinate mononucleotide and diphosphate from nicotinic acid and phosphoribosyl diphosphate in a steady-state reaction, the enzyme undergoes phosphorylation in His-219 by bound ATP, phosphorylated enzyme has higher affinity for substrates than does nonphosphorylated enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
r | |
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ITP + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | beta-nicotinate D-ribonucleotide + diphosphate + IDP + phosphate | - |
? | |
6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ITP + H2O | 5-phospho-alpha-D-ribose 1-diphosphate in complex with Mg | Salmonella enterica subsp. enterica serovar Typhimurium | beta-nicotinate D-ribonucleotide + diphosphate + IDP + phosphate | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.3.4.21 | ATP | reaction accelerated 10-30fold | Salmonella enterica subsp. enterica serovar Typhimurium | |
6.3.4.21 | ITP | - |
Salmonella enterica subsp. enterica serovar Typhimurium |