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Literature summary extracted from
- Yeast nicotinic acid phosphoribosyltransferase. Studies of reaction paths, phosphoenzyme, and Mg2+ effects (1977), Arch. Biochem. Biophys., 179, 334-341.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.3.4.21 | 5-phospho-alpha-D-ribose 1-diphosphate | at high concentrations, when Mg2+ below 0.03 mM | Saccharomyces cerevisiae |  |
| 6.3.4.21 | ATP | at high concentrations with Mg2+ below 0.03 mM | Saccharomyces cerevisiae | |
| 6.3.4.21 | MgADP- | non-competitive to Mg-ATP or Mg-diphosphate | Saccharomyces cerevisiae | |
| 6.3.4.21 | nicotinate mononucleotide | competitive to MgATP2-; non-competitive to nicotinate | Saccharomyces cerevisiae | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.3.4.21 | Mg2+ | requirement | Saccharomyces cerevisiae | |
| 6.3.4.21 | Mg2+ | 0.5-15 mM | Saccharomyces cerevisiae | |
| 6.3.4.21 | phosphate | 50 mM, strongly stimulates | Saccharomyces cerevisiae | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.3.4.21 | Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 6.3.4.21 | - |
Saccharomyces cerevisiae |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | sequential steady state mechanism | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.3.4.21 | nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | - |
Saccharomyces cerevisiae | beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 6.3.4.21 | nicotinate phosphoribosyltransferase | - |
- |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 6.3.4.21 | 37 | - |
assay at | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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