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Literature summary extracted from

  • Gaut, Z.N.; Solomon, H.M.
    Inhibition of nicotinate phosphoribosyltransferase in human platelet lysate by nicotinic acid analogs (1971), Biochem. Pharmacol., 20, 2903-2906.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.21 additional information no inhibition by 4-hydroxy-nicotinate Homo sapiens
6.3.4.21 Nicotinate analogues
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.21 0.024
-
 nicotinate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.21 Mg2+ requirement Homo sapiens
6.3.4.21 Mg2+ synergism with ATP Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.21 blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.21 additional information one mol ATP is cleaved per mol product formed Homo sapiens ?
-
 ?
6.3.4.21 additional information no ATPase activity in the absence of substrates Homo sapiens ?
-
 ?
6.3.4.21 nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O the pyridine N and carboxyl groups are important for interaction with the enzyme Homo sapiens beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.3.4.21 37
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.4.21 ATP 1 mol ATP is hydrolyzed to ADP plus phosphate per mol product formed Homo sapiens
6.3.4.21 ATP together with Mg2+ Homo sapiens