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Literature summary extracted from

  • Chakrabarti, D.; Da Silva, T.; Barger, J.; Paquette, S.; Patel, H.; Patterson, S.; Allen, C.M.
    Protein Farnesyltransferase and protein prenylation in Plasmodium falciparum (2002), J. Biol. Chem., 277, 42066-42073.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.5.1.58 medicine enzyme a target in developing drug therapy for malaria Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.58 FTI-277
-
 Plasmodium falciparum
2.5.1.58 GGTI-298
-
 Plasmodium falciparum
2.5.1.58 additional information
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.58 farnesyl diphosphate + protein-cysteine Plasmodium falciparum potential role for cell cycle S-farnesyl protein + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.58 Plasmodium falciparum
-
 protozoa malaria parasite, infected erythrocytes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.58 additional information appearance during specific stages of Plasmodium falciparum differentiation Plasmodium falciparum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.58 farnesyl diphosphate + protein-cysteine
-
 Plasmodium falciparum diphosphate + S-farnesyl protein
-
 ?
2.5.1.58 farnesyl diphosphate + protein-cysteine potential role for cell cycle Plasmodium falciparum S-farnesyl protein + diphosphate
-
 ?