BRENDA - Enzyme Database

Stability of dactimicin to aminoglycoside-modifying enzymes produced by 341 bacterial clinical isolates

Gomez-Lus, R.; Gomez-Lus, S.; Goni, M.P.; Rivera, M.J.; Martin, C.; Rubio-Calvo, M.C.; Drugs Exp. Clin. Res. 15, 129-132 (1989)

Data extracted from this reference:

Organism
EC Number
Organism
UniProt
Commentary
Textmining
2.3.1.81
Escherichia coli
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2.3.1.81
acetyl-CoA + dactimicin
the percentage of dactimicin affinity relative to gentamicin C1a is very high (74.6%) only with AAC(3)-I, to the most other enzymes tested, in spite of the bifunctional AAC(6')/APH(2''), dactamicin is stable
637305
Escherichia coli
CoA + N4-acetyldactamicin + N4,N6'-diacetyldactimicin
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1a
-
637305
Escherichia coli
CoA + N3'-acetylgentamicin C1a
-
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2.3.1.81
acetyl-CoA + dactimicin
the percentage of dactimicin affinity relative to gentamicin C1a is very high (74.6%) only with AAC(3)-I, to the most other enzymes tested, in spite of the bifunctional AAC(6')/APH(2''), dactamicin is stable
637305
Escherichia coli
CoA + N4-acetyldactamicin + N4,N6'-diacetyldactimicin
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1a
-
637305
Escherichia coli
CoA + N3'-acetylgentamicin C1a
-
-
-
?