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Literature summary extracted from

  • Williams, J.W.; Northrop, D.B.
    Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values (1978), J. Biol. Chem., 253, 5908-5914.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.60 2-deoxystreptamine weak Escherichia coli
2.3.1.60 amikacin i.e. BB-K 8 Escherichia coli
2.3.1.60 garamine
-
 Escherichia coli
2.3.1.60 Kanamine
-
 Escherichia coli
2.3.1.60 kanamycin A
-
 Escherichia coli
2.3.1.60 kanamycin C
-
 Escherichia coli
2.3.1.60 lividomycin
-
 Escherichia coli
2.3.1.60 Lividomycin B
-
 Escherichia coli
2.3.1.60 additional information inhibition kinetics Escherichia coli
2.3.1.60 neomycin best inhibitor Escherichia coli
2.3.1.60 paromomycin
-
 Escherichia coli
2.3.1.60 Paromomycin I
-
 Escherichia coli
2.3.1.60 ribostamycin
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.60 additional information
-
 additional information kinetic pattern Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.60 Escherichia coli
-
 containing R-factor JR88
-
2.3.1.60 Escherichia coli C600
-
 containing R-factor JR88
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.60 acetyl-CoA + fortimicin A
-
 Escherichia coli CoA + N2'-acetylfortimicin A
-
 ?
2.3.1.60 acetyl-CoA + gentamicin A
-
 Escherichia coli CoA + N3'-acetylgentamicin A
-
 ?
2.3.1.60 acetyl-CoA + gentamicin B
-
 Escherichia coli CoA + N3'-acetylgentamicin B
-
 ?
2.3.1.60 acetyl-CoA + gentamicin B1
-
 Escherichia coli CoA + N3'-acetylgentamicin B1
-
 ?
2.3.1.60 acetyl-CoA + gentamicin C1
-
 Escherichia coli CoA + N3'-acetylgentamicin C1
-
 ?
2.3.1.60 acetyl-CoA + gentamicin C1a best substrate Escherichia coli CoA + N3'-acetylgentamicin C1a
-
 ?
2.3.1.60 acetyl-CoA + gentamicin C1a enzyme modifies the 3-N-position of the deoxystreptamine ring Escherichia coli CoA + N3'-acetylgentamicin C1a
-
 ?
2.3.1.60 acetyl-CoA + gentamicin C1a best substrate Escherichia coli C600 CoA + N3'-acetylgentamicin C1a
-
 ?
2.3.1.60 acetyl-CoA + gentamicin C1a enzyme modifies the 3-N-position of the deoxystreptamine ring Escherichia coli C600 CoA + N3'-acetylgentamicin C1a
-
 ?
2.3.1.60 acetyl-CoA + gentamicin C2
-
 Escherichia coli CoA + N3'-acetylgentamicin C2
-
 ?
2.3.1.60 acetyl-CoA + gentamicin XK62-2
-
 Escherichia coli CoA + N3'-acetylgentamicin XK62-2
-
 ?
2.3.1.60 acetyl-CoA + kanamycin B
-
 Escherichia coli CoA + N3'-acetylkanamycin B
-
 ?
2.3.1.60 acetyl-CoA + N-ethylsisomicin
-
 Escherichia coli CoA + N3'-acetylethylsisomicin
-
 ?
2.3.1.60 acetyl-CoA + neamine
-
 Escherichia coli CoA + N3'-acetylneamine
-
 ?
2.3.1.60 acetyl-CoA + nebramine
-
 Escherichia coli CoA + N2'-acetylnebramine
-
 ?
2.3.1.60 acetyl-CoA + sisomicin best substrate Escherichia coli CoA + N3'-acetylsisomicin
-
 ?
2.3.1.60 acetyl-CoA + sisomicin best substrate Escherichia coli C600 CoA + N3'-acetylsisomicin
-
 ?
2.3.1.60 acetyl-CoA + tobramycin
-
 Escherichia coli CoA + N3'-acetyltobramycin
-
 ?
2.3.1.60 acetyl-CoA + tobramycin
-
 Escherichia coli C600 CoA + N3'-acetyltobramycin
-
 ?
2.3.1.60 additional information substrate structure/activity relationship Escherichia coli ?
-
 ?
2.3.1.60 additional information substrate structure/activity relationship Escherichia coli C600 ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.60 25
-
 assay at Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.60 0.0004
-
 neomycin
-
 Escherichia coli
2.3.1.60 0.002
-
 lividomycin
-
 Escherichia coli
2.3.1.60 0.0036
-
 garamine
-
 Escherichia coli
2.3.1.60 0.0083
-
 paromomycin
-
 Escherichia coli
2.3.1.60 0.024
-
 amikacin
-
 Escherichia coli
2.3.1.60 0.026
-
 kanamycin C
-
 Escherichia coli
2.3.1.60 0.07
-
 ribostamycin
-
 Escherichia coli
2.3.1.60 0.093
-
 kanamycin A
-
 Escherichia coli
2.3.1.60 0.208
-
 Kanamine
-
 Escherichia coli
2.3.1.60 2
-
 2-deoxystreptamine
-
 Escherichia coli