Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate

Biddlecome, S.; Haas, M.; Davies, J.; Rane, D.F.; Daniels, P.J.L.; Antimicrob. Agents Chemother. 9, 951-955 (1976)

Data extracted from this reference:

EC Number

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Escherichia coli

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Pseudomonas aeruginosa

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Escherichia coli R135/C600

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Escherichia coli

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Pseudomonas aeruginosa

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Escherichia coli R135/C600

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + neomycin B

-

637299

Escherichia coli

CoA + ?

-

-

-

?

2.3.1.81

acetyl-CoA + paromomycin

not E. coli

637299

Escherichia coli

CoA + N3'-acetylparomomycin B

-

-

-

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Escherichia coli

CoA + N3'-acetylsisomicin

-

637299

Escherichia coli

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Pseudomonas aeruginosa

CoA + N3'-acetylsisomicin

-

637299

Pseudomonas aeruginosa

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetylsisomicin

-

637299

Pseudomonas aeruginosa Travers PST

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Escherichia coli R135/C600

CoA + N3'-acetylsisomicin

-

637299

Escherichia coli R135/C600

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Escherichia coli

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Pseudomonas aeruginosa

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Escherichia coli R135/C600

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Escherichia coli

?

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Pseudomonas aeruginosa

?

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Pseudomonas aeruginosa Travers PST

?

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Escherichia coli R135/C600

?

-

-

-

?

EC Number

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Escherichia coli

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Pseudomonas aeruginosa

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + gentamicin C1

-

637299

Escherichia coli R135/C600

CoA + N3'-acetylgentamicin C1

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Escherichia coli

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Pseudomonas aeruginosa

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + kanamycin A

-

637299

Escherichia coli R135/C600

CoA + N3'-acetylkanamycin A

-

-

-

?

2.3.1.81

acetyl-CoA + neomycin B

-

637299

Escherichia coli

CoA + ?

-

-

-

?

2.3.1.81

acetyl-CoA + paromomycin

not E. coli

637299

Escherichia coli

CoA + N3'-acetylparomomycin B

-

-

-

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Escherichia coli

CoA + N3'-acetylsisomicin

-

637299

Escherichia coli

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Pseudomonas aeruginosa

CoA + N3'-acetylsisomicin

-

637299

Pseudomonas aeruginosa

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetylsisomicin

-

637299

Pseudomonas aeruginosa Travers PST

?

2.3.1.81

acetyl-CoA + sisomicin

best substrate

637299

Escherichia coli R135/C600

CoA + N3'-acetylsisomicin

-

637299

Escherichia coli R135/C600

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Escherichia coli

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Pseudomonas aeruginosa

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Pseudomonas aeruginosa Travers PST

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

acetyl-CoA + tobramycin

-

637299

Escherichia coli R135/C600

CoA + N3'-acetyltobramycin

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Escherichia coli

?

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Pseudomonas aeruginosa

?

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Pseudomonas aeruginosa Travers PST

?

-

-

-

?

2.3.1.81

additional information

no substrates are amikacin

637299

Escherichia coli R135/C600

?

-

-

-

?