BRENDA - Enzyme Database

Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate

Biddlecome, S.; Haas, M.; Davies, J.; Rane, D.F.; Daniels, P.J.L.; Antimicrob. Agents Chemother. 9, 951-955 (1976)

Data extracted from this reference:

Organism
EC Number
Organism
UniProt
Commentary
Textmining
2.3.1.81
Escherichia coli
-
-
-
2.3.1.81
Escherichia coli R135/C600
-
-
-
2.3.1.81
Pseudomonas aeruginosa
-
-
-
2.3.1.81
Pseudomonas aeruginosa Travers PST
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Escherichia coli
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Pseudomonas aeruginosa
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Escherichia coli R135/C600
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Escherichia coli
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Pseudomonas aeruginosa
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Escherichia coli R135/C600
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + neomycin B
-
637299
Escherichia coli
CoA + ?
-
-
-
?
2.3.1.81
acetyl-CoA + paromomycin
not E. coli
637299
Escherichia coli
CoA + N3'-acetylparomomycin B
-
-
-
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Escherichia coli
CoA + N3'-acetylsisomicin
-
637299
Escherichia coli
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Pseudomonas aeruginosa
CoA + N3'-acetylsisomicin
-
637299
Pseudomonas aeruginosa
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetylsisomicin
-
637299
Pseudomonas aeruginosa Travers PST
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Escherichia coli R135/C600
CoA + N3'-acetylsisomicin
-
637299
Escherichia coli R135/C600
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Escherichia coli
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Pseudomonas aeruginosa
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Escherichia coli R135/C600
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Escherichia coli
?
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Pseudomonas aeruginosa
?
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Pseudomonas aeruginosa Travers PST
?
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Escherichia coli R135/C600
?
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.3.1.81
30
-
assay at
Escherichia coli
2.3.1.81
30
-
assay at
Pseudomonas aeruginosa
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Escherichia coli
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Pseudomonas aeruginosa
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + gentamicin C1
-
637299
Escherichia coli R135/C600
CoA + N3'-acetylgentamicin C1
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Escherichia coli
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Pseudomonas aeruginosa
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + kanamycin A
-
637299
Escherichia coli R135/C600
CoA + N3'-acetylkanamycin A
-
-
-
?
2.3.1.81
acetyl-CoA + neomycin B
-
637299
Escherichia coli
CoA + ?
-
-
-
?
2.3.1.81
acetyl-CoA + paromomycin
not E. coli
637299
Escherichia coli
CoA + N3'-acetylparomomycin B
-
-
-
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Escherichia coli
CoA + N3'-acetylsisomicin
-
637299
Escherichia coli
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Pseudomonas aeruginosa
CoA + N3'-acetylsisomicin
-
637299
Pseudomonas aeruginosa
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetylsisomicin
-
637299
Pseudomonas aeruginosa Travers PST
?
2.3.1.81
acetyl-CoA + sisomicin
best substrate
637299
Escherichia coli R135/C600
CoA + N3'-acetylsisomicin
-
637299
Escherichia coli R135/C600
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Escherichia coli
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Pseudomonas aeruginosa
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Pseudomonas aeruginosa Travers PST
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
acetyl-CoA + tobramycin
-
637299
Escherichia coli R135/C600
CoA + N3'-acetyltobramycin
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Escherichia coli
?
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Pseudomonas aeruginosa
?
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Pseudomonas aeruginosa Travers PST
?
-
-
-
?
2.3.1.81
additional information
no substrates are amikacin
637299
Escherichia coli R135/C600
?
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.3.1.81
30
-
assay at
Escherichia coli
2.3.1.81
30
-
assay at
Pseudomonas aeruginosa