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Literature summary extracted from

  • Melzer, M.; Heide, L.
    Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli (1994), Biochim. Biophys. Acta, 1212, 93-102.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.39 CHAPS 46% increase at 0.01% Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.39
-
 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.39 NaCl increasing concentrations in the presence of 5 mM Mg2+ result in inhibition Escherichia coli
2.5.1.39 sodium deoxycholate
-
 Escherichia coli
2.5.1.39 Triton X-100
-
 Escherichia coli
2.5.1.39 Tween 80
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.39 0.022
-
 farnesyl diphosphate pH 7.8, 37°C Escherichia coli
2.5.1.39 0.031
-
 solanesyl diphosphate pH 7.8, 37°C Escherichia coli
2.5.1.39 0.254
-
 geranylgeranyl diphosphate pH 7.8, 37°C Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.39 membrane
-
 Escherichia coli 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.39 Co2+ can replace Mg2+ to some extent Escherichia coli
2.5.1.39 Mg2+ optimum between 20 and 100 mM Escherichia coli
2.5.1.39 Mn2+ can replace Mg2+ to some extent Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.39 solanesyl diphosphate + 4-hydroxybenzoate Escherichia coli involved in the biosynthesis of ubiquinone diphosphate + 3-solanesyl-4-hydroxybenzoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.39 Escherichia coli
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.39 0.0006
-
 in the presence of 5 mM Co2+ Escherichia coli
2.5.1.39 0.0013
-
 in the presence of 5 mM Mn2+ Escherichia coli
2.5.1.39 0.014
-
 in the presence of 5 mM Mg2+ Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.39 farnesyl diphosphate + 4-hydroxybenzoate
-
 Escherichia coli farnesyl-4-hydroxybenzoate + diphosphate
-
 ?
2.5.1.39 geranyl diphosphate + 4-hydroxybenzoate
-
 Escherichia coli 3-geranyl-4-hydroxybenzoate + diphosphate
-
 ?
2.5.1.39 geranylgeranyl diphosphate + 4-hydroxybenzoate
-
 Escherichia coli geranylgeranyl-4-hydroxybenzoate + diphosphate
-
 ?
2.5.1.39 solanesyl diphosphate + 4-hydroxybenzoate
-
 Escherichia coli diphosphate + 3-solanesyl-4-hydroxybenzoate
-
 ?
2.5.1.39 solanesyl diphosphate + 4-hydroxybenzoate involved in the biosynthesis of ubiquinone Escherichia coli diphosphate + 3-solanesyl-4-hydroxybenzoate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.39 7.8
-
-
 Escherichia coli

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.5.1.39 6.7 9.4 50% activity at pH 6.7 and pH 9.4 Escherichia coli