EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.60 | hydroxylamine | - |
Macaca fuscata | |
2.6.1.60 | hydroxylamine | - |
Rattus norvegicus | |
2.6.1.60 | Isonicotinic hydrazide | - |
Macaca fuscata | |
2.6.1.60 | Isonicotinic hydrazide | - |
Rattus norvegicus | |
2.6.1.60 | KCN | - |
Macaca fuscata | |
2.6.1.60 | KCN | - |
Rattus norvegicus | |
2.6.1.60 | Semicarbazide | strong | Macaca fuscata | |
2.6.1.60 | Semicarbazide | strong | Rattus norvegicus | |
2.6.1.63 | hydroxylamine | - |
Macaca fuscata | |
2.6.1.63 | hydroxylamine | - |
Rattus norvegicus | |
2.6.1.63 | Isonicotinic hydrazide | - |
Macaca fuscata | |
2.6.1.63 | Isonicotinic hydrazide | - |
Rattus norvegicus | |
2.6.1.63 | KCN | - |
Macaca fuscata | |
2.6.1.63 | KCN | - |
Rattus norvegicus | |
2.6.1.63 | Semicarbazide | - |
Macaca fuscata | |
2.6.1.63 | Semicarbazide | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.60 | 0.4 | - |
glyoxylate | cosubstrate L-kynurenine, pH 8.0, 37°C | Macaca fuscata | |
2.6.1.60 | 0.5 | - |
glyoxylate | L-kynurenine, pH 8.0, 37°C | Rattus norvegicus | |
2.6.1.60 | 1.2 | - |
L-kynurenine | glyoxylate, pH 8.0, 37°C | Rattus norvegicus | |
2.6.1.60 | 1.5 | - |
L-kynurenine | cosubstrate glyoxylate, pH 8.0, 37°C | Macaca fuscata | |
2.6.1.63 | 0.4 | - |
glyoxylate | - |
Macaca fuscata | |
2.6.1.63 | 0.5 | - |
glyoxylate | - |
Rattus norvegicus | |
2.6.1.63 | 1.2 | - |
L-kynurenine | - |
Rattus norvegicus | |
2.6.1.63 | 1.5 | - |
L-kynurenine | - |
Macaca fuscata |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.6.1.60 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
2.6.1.60 | mitochondrion | - |
Macaca fuscata | 5739 | - |
2.6.1.63 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
2.6.1.63 | mitochondrion | - |
Macaca fuscata | 5739 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.6.1.60 | 40000 | - |
2 * 40000, SDS-PAGE | Rattus norvegicus |
2.6.1.60 | 40000 | - |
2 * 40000, SDS-PAGE | Macaca fuscata |
2.6.1.60 | 80000 | - |
gel filtration | Rattus norvegicus |
2.6.1.60 | 80000 | - |
gel filtration | Macaca fuscata |
2.6.1.63 | 40000 | - |
2 * 40000, SDS-PAGE | Rattus norvegicus |
2.6.1.63 | 40000 | - |
2 * 40000, SDS-PAGE | Macaca fuscata |
2.6.1.63 | 80000 | - |
gel filtration | Rattus norvegicus |
2.6.1.63 | 80000 | - |
gel filtration | Macaca fuscata |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.60 | an aromatic amino acid + glyoxylate | Rattus norvegicus | - |
an aromatic oxo acid + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | Rattus norvegicus | glucagon inducible enzyme | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | Macaca fuscata | glucagon inducible enzyme | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | Rattus norvegicus Donryu | glucagon inducible enzyme | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.60 | Macaca fuscata | - |
Blyth monkey | - |
2.6.1.60 | Rattus norvegicus | - |
- |
- |
2.6.1.63 | Macaca fuscata | - |
Blyth monkey | - |
2.6.1.63 | Rattus norvegicus | - |
Donryu strain | - |
2.6.1.63 | Rattus norvegicus Donryu | - |
Donryu strain | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.60 | - |
Rattus norvegicus |
2.6.1.60 | partial | Macaca fuscata |
2.6.1.63 | - |
Rattus norvegicus |
2.6.1.63 | - |
Macaca fuscata |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.6.1.60 | liver | - |
Rattus norvegicus | - |
2.6.1.60 | liver | - |
Macaca fuscata | - |
2.6.1.63 | liver | - |
Rattus norvegicus | - |
2.6.1.63 | liver | - |
Macaca fuscata | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.60 | 0.105 | - |
pH 7.5, 37°C | Macaca fuscata |
2.6.1.60 | 0.223 | - |
pH 7.5, 37°C | Rattus norvegicus |
EC Number | Storage Stability | Organism |
---|---|---|
2.6.1.60 | -20°C, at least 4 weeks | Macaca fuscata |
2.6.1.60 | -20°C, at least 7 weeks | Rattus norvegicus |
2.6.1.60 | 0-4°C, 2 weeks with little or no loss of activity | Macaca fuscata |
2.6.1.60 | 0-4°C, 3 weeks with little or no loss of activity respectively | Rattus norvegicus |
2.6.1.63 | -20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 4 weeks | Macaca fuscata |
2.6.1.63 | -20°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, at least 7 weeks | Rattus norvegicus |
2.6.1.63 | 0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal 5-phosphate, 5 mM 2-mercaptoethanol, 20% glycerol, 2 weeks | Macaca fuscata |
2.6.1.63 | 0-4°C, in 50 mM potassium phosphate buffer, pH 7.5, 0.2 mM pyridoxal phosphate, 5 mM mercaptoethanol, 20% glycerol, 3 weeks | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.60 | 5-hydroxytryptophan + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 3-(5-hydroxyindole)-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | 5-hydroxytryptophan + glyoxylate | less efficient amino group donor than L-phenylalanine | Macaca fuscata | 3-(5-hydroxyindole)-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | an aromatic amino acid + glyoxylate | - |
Rattus norvegicus | an aromatic oxo acid + glycine | - |
? | |
2.6.1.60 | L-histidine + glyoxylate | - |
Rattus norvegicus | 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | L-histidine + glyoxylate | - |
Macaca fuscata | 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | L-kynurenine + glyoxylate | - |
Macaca fuscata | 3-(2-aminophenyl-)2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.60 | L-kynurenine + glyoxylate | poor amino group donor | Rattus norvegicus | 3-(2-aminophenyl-)2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.60 | L-phenylalanine + 2-oxo-4-methylthiobutyrate | - |
Rattus norvegicus | phenylpyruvate + L-methionine | - |
? | |
2.6.1.60 | L-phenylalanine + 2-oxo-4-methylthiobutyrate | - |
Macaca fuscata | phenylpyruvate + L-methionine | - |
? | |
2.6.1.60 | L-phenylalanine + 2-oxoglutarate | - |
Rattus norvegicus | phenylpyruvate + L-glutamate | - |
? | |
2.6.1.60 | L-phenylalanine + 2-oxoglutarate | - |
Macaca fuscata | phenylpyruvate + L-glutamate | - |
? | |
2.6.1.60 | L-phenylalanine + glyoxylate | - |
Rattus norvegicus | phenylpyruvate + glycine | - |
? | |
2.6.1.60 | L-phenylalanine + glyoxylate | - |
Macaca fuscata | phenylpyruvate + glycine | - |
? | |
2.6.1.60 | L-phenylalanine + hydroxypyruvate | - |
Rattus norvegicus | phenylpyruvate + L-serine | - |
? | |
2.6.1.60 | L-phenylalanine + hydroxypyruvate | - |
Macaca fuscata | phenylpyruvate + L-serine | - |
? | |
2.6.1.60 | L-phenylalanine + pyruvate | - |
Rattus norvegicus | phenylpyruvate + L-alanine | - |
? | |
2.6.1.60 | L-phenylalanine + pyruvate | - |
Macaca fuscata | phenylpyruvate + L-alanine | - |
? | |
2.6.1.60 | tryptophan + glyoxylate | less efficient amino group donor than L-phenylalanine | Rattus norvegicus | 3-indole-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | tryptophan + glyoxylate | less efficient amino group donor than L-phenylalanine | Macaca fuscata | 3-indole-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | tyrosine + glyoxylate | - |
Rattus norvegicus | 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.60 | tyrosine + glyoxylate | - |
Macaca fuscata | 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | 5-hydroxytryptophan + glyoxylate | - |
Rattus norvegicus | 3-(5-hydroxyindole)-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | 5-hydroxytryptophan + glyoxylate | - |
Macaca fuscata | 3-(5-hydroxyindole)-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | histidine + glyoxylate | - |
Rattus norvegicus | 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | histidine + glyoxylate | - |
Macaca fuscata | 3-(1H-imidazol-4-yl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + 2-oxoglutarate | - |
Rattus norvegicus | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate | - |
? | |
2.6.1.63 | L-kynurenine + 4-methylsulfanyl-2-oxobutanoate | - |
Rattus norvegicus | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine | - |
? | |
2.6.1.63 | L-kynurenine + 4-methylsulfanyl-2-oxobutanoate | - |
Macaca fuscata | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine | - |
? | |
2.6.1.63 | L-kynurenine + 4-methylsulfanyl-2-oxobutanoate | - |
Rattus norvegicus Donryu | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-methionine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | - |
Rattus norvegicus | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | - |
Macaca fuscata | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | glucagon inducible enzyme | Rattus norvegicus | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | glucagon inducible enzyme | Macaca fuscata | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | - |
Rattus norvegicus Donryu | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + glyoxylate | glucagon inducible enzyme | Rattus norvegicus Donryu | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
2.6.1.63 | L-kynurenine + hydroxypyruvate | - |
Rattus norvegicus | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine | - |
? | |
2.6.1.63 | L-kynurenine + hydroxypyruvate | - |
Macaca fuscata | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine | - |
? | |
2.6.1.63 | L-kynurenine + hydroxypyruvate | - |
Rattus norvegicus Donryu | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-serine | - |
? | |
2.6.1.63 | L-kynurenine + pyruvate | - |
Rattus norvegicus | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine | - |
? | |
2.6.1.63 | L-kynurenine + pyruvate | - |
Macaca fuscata | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine | - |
? | |
2.6.1.63 | L-kynurenine + pyruvate | - |
Rattus norvegicus Donryu | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine | - |
? | |
2.6.1.63 | phenylalanine + glyoxylate | - |
Rattus norvegicus | phenylpyruvate + glycine | - |
? | |
2.6.1.63 | phenylalanine + glyoxylate | - |
Macaca fuscata | phenylpyruvate + glycine | - |
? | |
2.6.1.63 | tryptophan + glyoxylate | - |
Rattus norvegicus | 3-indole-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | tryptophan + glyoxylate | - |
Macaca fuscata | 3-indole-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | tyrosine + glyoxylate | - |
Rattus norvegicus | 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine | - |
? | |
2.6.1.63 | tyrosine + glyoxylate | - |
Macaca fuscata | 3-(4-hydroxyphenyl)-2-oxopropanoate + glycine | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.6.1.60 | dimer | 2 * 40000, SDS-PAGE | Rattus norvegicus |
2.6.1.60 | dimer | 2 * 40000, SDS-PAGE | Macaca fuscata |
2.6.1.63 | dimer | 2 * 40000, SDS-PAGE | Rattus norvegicus |
2.6.1.63 | dimer | 2 * 40000, SDS-PAGE | Macaca fuscata |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.60 | 37 | - |
assay at | Rattus norvegicus |
2.6.1.60 | 37 | - |
assay at | Macaca fuscata |
2.6.1.63 | 37 | - |
assay at | Rattus norvegicus |
2.6.1.63 | 37 | - |
assay at | Macaca fuscata |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.63 | 70 | - |
t1/2: 25 min | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.60 | additional information | - |
pI: 8 | Rattus norvegicus |
2.6.1.60 | additional information | - |
pI: 8 | Macaca fuscata |
2.6.1.60 | 8 | 8.5 | - |
Rattus norvegicus |
2.6.1.60 | 8 | 8.5 | - |
Macaca fuscata |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.60 | pyridoxal 5'-phosphate | requirement | Rattus norvegicus | |
2.6.1.60 | pyridoxal 5'-phosphate | requirement | Macaca fuscata | |
2.6.1.63 | pyridoxal 5'-phosphate | requirement, tightly bound | Rattus norvegicus | |
2.6.1.63 | pyridoxal 5'-phosphate | requirement, tightly bound | Macaca fuscata |