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Literature summary extracted from

  • Peterkofsky, B.; Gilvarg, C.
    N-succinyl-L-diaminopimelic-glutamic transaminase (1961), J. Biol. Chem., 236, 1432-1438.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.17 (NH4)2SO4
-
 Escherichia coli
2.6.1.17 2-oxoglutarate at high concentrations, inhibition in both directions Escherichia coli
2.6.1.17 hydroxylamine
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.17 0.5
-
 N-Succinyl-2-amino-6-oxoheptanedioate pH 7.4 Escherichia coli
2.6.1.17 5.2
-
 L-glutamate pH 7.4 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Lactiplantibacillus plantarum
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Alcaligenes faecalis
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Escherichia coli
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Cereibacter sphaeroides
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Klebsiella aerogenes
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Micrococcus luteus
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Azotobacter vinelandii
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate Desmonostoc muscorum
-
 N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.17 Alcaligenes faecalis
-
-
-
2.6.1.17 Azotobacter vinelandii
-
-
-
2.6.1.17 Cereibacter sphaeroides
-
-
-
2.6.1.17 Desmonostoc muscorum
-
-
-
2.6.1.17 Escherichia coli
-
-
-
2.6.1.17 Klebsiella aerogenes
-
-
-
2.6.1.17 Lactiplantibacillus plantarum
-
-
-
2.6.1.17 Micrococcus luteus
-
-
-
2.6.1.17 no activity in Brewer's yeast
-
-
-
2.6.1.17 no activity in Lactobacillus casei
-
-
-
2.6.1.17 no activity in Streptococcus sp.
-
-
-
2.6.1.17 no activity in Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.17
-
 Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.17 5.33
-
 pH 7.4 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Lactiplantibacillus plantarum N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Lactiplantibacillus plantarum N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Alcaligenes faecalis N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Alcaligenes faecalis N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Escherichia coli N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Cereibacter sphaeroides N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Cereibacter sphaeroides N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Klebsiella aerogenes N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Klebsiella aerogenes N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Micrococcus luteus N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Micrococcus luteus N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Azotobacter vinelandii N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Azotobacter vinelandii N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Desmonostoc muscorum N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 ?
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate
-
 Desmonostoc muscorum N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r
2.6.1.17 N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate completely specific towards L-glutamate Escherichia coli N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.17 7.4
-
 assay at Escherichia coli
2.6.1.17 8
-
-
 Escherichia coli

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.17 6.5 9 pH 6.5: about 25% of maximum activity, pH 9: about 60% of maximum activity Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.17 pyridoxal 5'-phosphate a pyridoxal phosphate protein Escherichia coli