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Literature summary extracted from

  • Magnet, S.; Lambert, T.; Courvalin, P.; Blanchard, J.S.
    Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase (2001), Biochemistry, 40, 3700-3709.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.82
-
Salmonella enterica

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.82 C109A mutation neither abolishes activity nor alters the biphasic inactivation by iodoacetamide Salmonella enterica

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.82 dithio-CoA
-
Salmonella enterica
2.3.1.82 iodoacetamide inactivation in a biphasic manner, half of the activity is lost rapidly and the other half more slowly, tobramycin but not acetyl-CoA protects Salmonella enterica
2.3.1.82 lividomycin
-
Salmonella enterica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.82 0.006
-
netilmicin mutant enzyme C109A Salmonella enterica
2.3.1.82 0.008
-
netilmicin wild-type enzyme Salmonella enterica
2.3.1.82 0.01
-
acetyl-CoA reaction with tobramycin Salmonella enterica
2.3.1.82 0.012
-
sisomicin wild-type enzyme Salmonella enterica
2.3.1.82 0.014
-
neomycin C wild-type enzyme Salmonella enterica
2.3.1.82 0.017
-
kanamycin B mutant enzyme C109A Salmonella enterica
2.3.1.82 0.017
-
acetyl-CoA reaction with tobramycin, mutant enzyme C109A Salmonella enterica
2.3.1.82 0.026
-
tobramycin mutant enzyme C109A Salmonella enterica
2.3.1.82 0.03
-
dibekacin wild-type enzyme Salmonella enterica
2.3.1.82 0.05
-
amikacin wild-type enzyme Salmonella enterica
2.3.1.82 0.05
-
ribostamycin wild-type enzyme Salmonella enterica
2.3.1.82 0.066
-
tobramycin wild-type enzyme Salmonella enterica
2.3.1.82 0.07
-
acetyl-CoA reaction with tobramycin, mutant enzyme C109A/C70A Salmonella enterica
2.3.1.82 0.075
-
amikacin mutant enzyme C109A Salmonella enterica
2.3.1.82 0.079
-
kanamycin B wild-type enzyme Salmonella enterica
2.3.1.82 0.105
-
kanamycin A wild-type enzyme Salmonella enterica
2.3.1.82 0.25
-
neomycin C mutant enzyme C109A/C70A Salmonella enterica
2.3.1.82 0.27
-
propionyl-CoA reaction with tobramycin, wild-type enzyme Salmonella enterica
2.3.1.82 0.46
-
netilmicin mutant enzyme C109A/C70A Salmonella enterica
2.3.1.82 0.53
-
neomycin A
-
Salmonella enterica
2.3.1.82 0.54
-
tobramycin mutant enzyme C109A/C70A Salmonella enterica
2.3.1.82 0.82
-
malonyl-CoA reaction with tobramycin, wild-type enzyme Salmonella enterica
2.3.1.82 0.9
-
kanamycin B mutant enzyme C109A/C70A Salmonella enterica
2.3.1.82 9.3
-
butyryl-CoA reaction with tobramycin, wild-type enzyme Salmonella enterica

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.82 17000
-
2 * 17000, SDS-PAGE Salmonella enterica
2.3.1.82 17173
-
2 * 17173, calculation from nucleotide sequence Salmonella enterica
2.3.1.82 17184
-
2 * 17184, electrospray ionization mass spectrometry Salmonella enterica
2.3.1.82 35000
-
gel filtration Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.82 additional information Salmonella enterica involved in resistance to antibiotics ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Salmonella enterica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + amikacin
-
Salmonella enterica CoA + N6'-acetylamikacin
-
?
2.3.1.82 acetyl-CoA + dibekacin
-
Salmonella enterica CoA + N6'-acetyldibekacin
-
?
2.3.1.82 acetyl-CoA + kanamycin A
-
Salmonella enterica CoA + N6'-acetylkanamycin A
-
?
2.3.1.82 acetyl-CoA + kanamycin B
-
Salmonella enterica CoA + N6'-acetylkanamycin B
-
?
2.3.1.82 acetyl-CoA + neomycin A
-
Salmonella enterica CoA + N6'-acetylneomycin A
-
?
2.3.1.82 acetyl-CoA + neomycin C
-
Salmonella enterica CoA + N6'-acetylneomycin C
-
?
2.3.1.82 acetyl-CoA + netilmicin
-
Salmonella enterica CoA + N6'-acetylnetilmicin
-
?
2.3.1.82 acetyl-CoA + ribostamycin
-
Salmonella enterica CoA + N6'-acetylribostamycin
-
?
2.3.1.82 acetyl-CoA + sisomicin
-
Salmonella enterica CoA + N6'-acetylsisomicin
-
?
2.3.1.82 acetyl-CoA + tobramycin
-
Salmonella enterica CoA + N6'-acetyltobramycin
-
?
2.3.1.82 butyryl-CoA + tobramycin
-
Salmonella enterica CoA + N6'-butyryltobramycin
-
?
2.3.1.82 malonyl-CoA + tobramycin
-
Salmonella enterica CoA + N6'-malonyltobramycin
-
?
2.3.1.82 additional information involved in resistance to antibiotics Salmonella enterica ?
-
?
2.3.1.82 propionyl-CoA + tobramycin tobramycin exhibits a rapid, tobramycin-independent rate of hydrolysis that is linearly proportional to enzyme Salmonella enterica CoA + N6'-propionyltobramycin
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.82 dimer 2 * 17000, SDS-PAGE Salmonella enterica
2.3.1.82 dimer 2 * 17173, calculation from nucleotide sequence Salmonella enterica
2.3.1.82 dimer 2 * 17184, electrospray ionization mass spectrometry Salmonella enterica