BRENDA - Enzyme Database

Aminoglycoside 6'-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii

Casin, I.; Bordon, F.; Bertin, P.; Coutrot, A.; Podglajen, I.; Brasseur, R.; Collatz, E.; Antimicrob. Agents Chemother. 42, 209-215 (1998)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.82
additional information
Enterobacter cloacae
involved in resistance to antibiotics
?
-
-
-
2.3.1.82
additional information
Citrobacter freundii
involved in resistance to antibiotics
?
-
-
-
2.3.1.82
additional information
Enterobacter cloacae EC 1562
involved in resistance to antibiotics
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.82
Citrobacter freundii
-
enzyme variant with Ser119
-
2.3.1.82
Enterobacter cloacae
-
and strain EC1563, enzyme variant with Ser119, cinical isolates
-
2.3.1.82
Enterobacter cloacae EC 1562
-
and strain EC1563, enzyme variant with Ser119, cinical isolates
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.82
acetyl-CoA + amikacin
the enzyme variant of enzyme type Ib has at position 119 a Ser instead of the Leu, conferring resistance to amikacin
636907
Enterobacter cloacae
CoA + N6'-acetylamikacin
-
-
-
?
2.3.1.82
acetyl-CoA + amikacin
the enzyme variant of enzyme type Ib has at position 119 a Ser instead of the Leu, conferring resistance to amikacin
636907
Citrobacter freundii
CoA + N6'-acetylamikacin
-
-
-
?
2.3.1.82
acetyl-CoA + amikacin
the enzyme variant of enzyme type Ib has at position 119 a Ser instead of the Leu, conferring resistance to amikacin
636907
Enterobacter cloacae EC 1562
CoA + N6'-acetylamikacin
-
-
-
?
2.3.1.82
additional information
involved in resistance to antibiotics
636907
Enterobacter cloacae
?
-
-
-
-
2.3.1.82
additional information
involved in resistance to antibiotics
636907
Citrobacter freundii
?
-
-
-
-
2.3.1.82
additional information
involved in resistance to antibiotics
636907
Enterobacter cloacae EC 1562
?
-
-
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.82
additional information
Enterobacter cloacae
involved in resistance to antibiotics
?
-
-
-
2.3.1.82
additional information
Citrobacter freundii
involved in resistance to antibiotics
?
-
-
-
2.3.1.82
additional information
Enterobacter cloacae EC 1562
involved in resistance to antibiotics
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.82
acetyl-CoA + amikacin
the enzyme variant of enzyme type Ib has at position 119 a Ser instead of the Leu, conferring resistance to amikacin
636907
Enterobacter cloacae
CoA + N6'-acetylamikacin
-
-
-
?
2.3.1.82
acetyl-CoA + amikacin
the enzyme variant of enzyme type Ib has at position 119 a Ser instead of the Leu, conferring resistance to amikacin
636907
Citrobacter freundii
CoA + N6'-acetylamikacin
-
-
-
?
2.3.1.82
acetyl-CoA + amikacin
the enzyme variant of enzyme type Ib has at position 119 a Ser instead of the Leu, conferring resistance to amikacin
636907
Enterobacter cloacae EC 1562
CoA + N6'-acetylamikacin
-
-
-
?
2.3.1.82
additional information
involved in resistance to antibiotics
636907
Enterobacter cloacae
?
-
-
-
-
2.3.1.82
additional information
involved in resistance to antibiotics
636907
Citrobacter freundii
?
-
-
-
-
2.3.1.82
additional information
involved in resistance to antibiotics
636907
Enterobacter cloacae EC 1562
?
-
-
-
-