EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.66 | Acetylsalicylic acid | aspirin | Homo sapiens | |
2.4.1.66 | ADP | - |
Homo sapiens | |
2.4.1.66 | AMP | - |
Homo sapiens | |
2.4.1.66 | cAMP | 4.5 mM: 26% inhibition | Homo sapiens | |
2.4.1.66 | D-glucosamine | - |
Homo sapiens | |
2.4.1.66 | additional information | not inhibited by D-glucose, N-acetylglucosamine, N-acteylgalactosamine, Triton X-100, delta-hydroxylysine | Homo sapiens | |
2.4.1.66 | p-hydroxymercuribenzoate | 1 mM: complete inhibition | Homo sapiens | |
2.4.1.66 | UDP | product inhibition | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.66 | membrane | membrane-bound | Homo sapiens | 16020 | - |
2.4.1.66 | plasma membrane | found primarily in | Homo sapiens | 5886 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.66 | Ca2+ | activates, 20% as effective as Mn2+ | Homo sapiens | |
2.4.1.66 | Co2+ | activates, 20% as effective as Mn2+ | Homo sapiens | |
2.4.1.66 | Mg2+ | activates, about 20% as effective as Mn2+ | Homo sapiens | |
2.4.1.66 | Mn2+ | requirement | Homo sapiens | |
2.4.1.66 | Mn2+ | 15 mM | Homo sapiens | |
2.4.1.66 | additional information | not activated by Cd2+ | Homo sapiens | |
2.4.1.66 | additional information | not activated by Zn2+, Cu2+ | Homo sapiens | |
2.4.1.66 | additional information | not activated by Na+, K+, Ba2+ | Homo sapiens | |
2.4.1.66 | additional information | not activated by Fe3+ | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | Homo sapiens | may play a major role in the mechanism of platelet:collagen adhesion | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.66 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.66 | 20fold | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.66 | blood platelet | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.66 | additional information | not: ovalbumin, transferrin, fetuin | Homo sapiens | ? | - |
? | |
2.4.1.66 | additional information | not: bovine and ovine submaxillary glycoprotein, ovalbumin, ceruloplasmin, human albumin, fibrinogen, haptoglobin, deaminated collagen, very poor glucosyl donors: UDPgalactose, ADPglucose | Homo sapiens | ? | - |
? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | specific for collagen | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | product is glucosylgalactosylhydroxylysine-collagen | ? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | incomplete hexasaccharide chains of bovine Achilles tendon collagen, glucosyl residues removed by mild acid hydrolysis | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | product is glucosylgalactosylhydroxylysine-collagen | ? | |
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | may play a major role in the mechanism of platelet:collagen adhesion | Homo sapiens | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? | |
2.4.1.66 | UDP-glucose + fetuin minus sialic acid, galactose and N-acetylglucosamine | 7% as effective as glucose-free bovine Achilles tendon collagen | Homo sapiens | ? | - |
? | |
2.4.1.66 | UDP-glucose + transferrin minus Fe3+ and sialic acid | 7% as effective as glucose-free bovine Achilles tendon collagen | Homo sapiens | ? | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.66 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.4.1.66 | 5.7 | - |
- |
Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.4.1.66 | 5.2 | 6.5 | about half-maximal activity at pH 5.2 and 6.5 | Homo sapiens |