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Literature summary extracted from

  • Mosca, M.; Croci, C.; Mostardini, M.; Breton, J.; Malyszko, J.; Avanzi, N.; Toma, S.; Benatti, L.; Gatti, S.
    Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs (2003), Biochim. Biophys. Acta, 1628, 1-10.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.7 expression of KAT I in Cos-1 cells Homo sapiens
2.6.1.15 4 cDNAs with different 5’-untranslated regions Rattus norvegicus
2.6.1.64
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.7 cytosol KAT I, the enzyme exists in a cytosolic and in a mitochondrial form because of the presence of 2 different KAT I mRNAs coding for a protein respectively with and without leader sequence targeting the protein into mitochondria Rattus norvegicus 5829
-
2.6.1.15 cytosol
-
 Rattus norvegicus 5829
-
2.6.1.15 mitochondrion
-
 Rattus norvegicus 5739
-
2.6.1.64 cytosol
-
 Rattus norvegicus 5829
-
2.6.1.64 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.15 44000
-
 x * 44000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.64 L-glutamine + phenylpyruvate Rattus norvegicus
-
 2-oxoglutaramate + L-phenylalanine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Homo sapiens
-
-
-
2.6.1.7 Rattus norvegicus Q08415 cytosolic KAT I
-
2.6.1.15 Rattus norvegicus
-
 bifunctional kynurenine aminotransferase/glutamine transaminase, 4 isoforms, expression in COS1-cells
-
2.6.1.64 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.15 kidney isoform +14KATI Rattus norvegicus
-
2.6.1.15 additional information most isoforms are ubiquitously expressed Rattus norvegicus
-
2.6.1.64 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.15 L-phenylalanine + 4-methylthio-2-oxobutanoate
-
 Rattus norvegicus phenylpyruvate + 2-amino-4-methylthiobutanoate
-
 ?
2.6.1.64 L-glutamine + phenylpyruvate
-
 Rattus norvegicus 2-oxoglutaramate + L-phenylalanine
-
 r

Subunits

EC Number Subunits Comment Organism
2.6.1.15 ? x * 44000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.6.1.15 KATI
-
 Rattus norvegicus
2.6.1.64 EC 2.6.1.15 identical with Rattus norvegicus
2.6.1.64 GTK
-
 Rattus norvegicus
2.6.1.64 KAT/GTK
-
 Rattus norvegicus
2.6.1.64 kynurenine aminotransferase/glutamine transaminase K
-
 Rattus norvegicus