BRENDA - Enzyme Database

Kynurenine aminotransferase I activity in human placenta

Milart, P.; Urbanska, E.M.; Turski, W.A.; Paszkowski, T.; Sikorski, R.; Placenta 22, 259-261 (2001)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
glutamine
0.08 mM; 50% inhibition of placental KAT I
Homo sapiens
2.6.1.7
L-phenylalanine
-
Homo sapiens
2.6.1.7
L-tryptophan
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.6.1.7
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
placenta
KAT I
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + pyruvate
placental KAT I, higher activity than with 2-oxoglutarate
636637
Homo sapiens
kynurenic acid + L-alanine + H2O
-
636637
Homo sapiens
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.6.1.7
8.8
-
total placental KAT activity
Homo sapiens
2.6.1.7
9.8
-
placental KAT I activity
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
glutamine
0.08 mM; 50% inhibition of placental KAT I
Homo sapiens
2.6.1.7
L-phenylalanine
-
Homo sapiens
2.6.1.7
L-tryptophan
-
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
placenta
KAT I
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + pyruvate
placental KAT I, higher activity than with 2-oxoglutarate
636637
Homo sapiens
kynurenic acid + L-alanine + H2O
-
636637
Homo sapiens
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.6.1.7
8.8
-
total placental KAT activity
Homo sapiens
2.6.1.7
9.8
-
placental KAT I activity
Homo sapiens