BRENDA - Enzyme Database

Kynurenic acid and kynurenine aminotransferase in heart

Baran, H.; Amann, G.; Lubec, B.; Lubec, G.; Pediatr. Res. 41, 404-410 (1997)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.6.1.7
L-tryptophan
2 mM, 84% increase in activity of heart KAT at pH 8.0
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
L-tryptophan
-
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.6.1.7
0.62
-
2-oxoglutarate
pH 8.0, 37°C, heart KAT, at 5 mM L-kynurenine
Homo sapiens
2.6.1.7
1.15
-
pyruvate
pH 8.0, 37°C, heart KAT, at 5 mM L-kynurenine
Homo sapiens
2.6.1.7
20
-
L-kynurenine
pH 8.0, 37°C, heart KAT, cosubstrate 5 mM pyruvate
Homo sapiens
2.6.1.7
27
-
L-kynurenine
pH 8.0, 37°C, heart KAT, cosubstrate 5 mM 2-oxoglutarate
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.6.1.7
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
heart
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + 2-oxoadipate
-
636633
Homo sapiens
kynurenic acid + 2-aminoadipate + H2O
-
636633
Homo sapiens
?
2.6.1.7
L-kynurenine + 2-oxoisohexanoate
heart KAT, low activity
636633
Homo sapiens
kynurenic acid + 2-aminoisohexanoate + H2O
-
636633
Homo sapiens
-
2.6.1.7
L-kynurenine + pyruvate
best substrate of heart KAT
636633
Homo sapiens
kynurenic acid + L-alanine + H2O
-
636633
Homo sapiens
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.6.1.7
8
9
heart enzyme
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.6.1.7
L-tryptophan
2 mM, 84% increase in activity of heart KAT at pH 8.0
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
L-tryptophan
-
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.6.1.7
0.62
-
2-oxoglutarate
pH 8.0, 37°C, heart KAT, at 5 mM L-kynurenine
Homo sapiens
2.6.1.7
1.15
-
pyruvate
pH 8.0, 37°C, heart KAT, at 5 mM L-kynurenine
Homo sapiens
2.6.1.7
20
-
L-kynurenine
pH 8.0, 37°C, heart KAT, cosubstrate 5 mM pyruvate
Homo sapiens
2.6.1.7
27
-
L-kynurenine
pH 8.0, 37°C, heart KAT, cosubstrate 5 mM 2-oxoglutarate
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
heart
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + 2-oxoadipate
-
636633
Homo sapiens
kynurenic acid + 2-aminoadipate + H2O
-
636633
Homo sapiens
?
2.6.1.7
L-kynurenine + 2-oxoisohexanoate
heart KAT, low activity
636633
Homo sapiens
kynurenic acid + 2-aminoisohexanoate + H2O
-
636633
Homo sapiens
-
2.6.1.7
L-kynurenine + pyruvate
best substrate of heart KAT
636633
Homo sapiens
kynurenic acid + L-alanine + H2O
-
636633
Homo sapiens
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.6.1.7
8
9
heart enzyme
Homo sapiens