BRENDA - Enzyme Database

Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome

Baran, H.; Cairns, N.; Lubec, B.; Lubec, G.; Life Sci. 58, 1891-1899 (1996)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
glutamine
0.08 mM; inhibition of KAT I
Homo sapiens
2.6.1.7
L-phenylalanine
inhibition of KAT I
Homo sapiens
2.6.1.7
L-tryptophan
inhibition of KAT I
Homo sapiens
2.6.1.7
additional information
KAT II is not inhibited by glutamine, tryptophan and phenylalanine
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.6.1.7
Homo sapiens
-
kynurenine aminotransferase I and II, i.e. KAT I and KAT II, in elderly Down syndrome patients
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
brain
frontal and temporal cortex
Homo sapiens
-
2.6.1.7
frontal lobe
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + 2-oxoglutarate
KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate
636627
Homo sapiens
kynurenic acid + L-glutamate + H2O
-
636627
Homo sapiens
-
2.6.1.7
L-kynurenine + 2-oxoisohexanoate
KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate
636627
Homo sapiens
kynurenic acid + 2-aminoisohexanoate + H2O
-
636627
Homo sapiens
?
2.6.1.7
L-kynurenine + pyruvate
KAT I shows far higher activity with 2-oxoisohexanoate and pyruvate than with 2-oxoglutarate
636627
Homo sapiens
kynurenic acid + L-alanine + H2O
-
636627
Homo sapiens
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.6.1.7
7
8
KAT II from brain
Homo sapiens
2.6.1.7
9.6
10
KAT I from brain, sharp optimum
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
glutamine
0.08 mM; inhibition of KAT I
Homo sapiens
2.6.1.7
L-phenylalanine
inhibition of KAT I
Homo sapiens
2.6.1.7
L-tryptophan
inhibition of KAT I
Homo sapiens
2.6.1.7
additional information
KAT II is not inhibited by glutamine, tryptophan and phenylalanine
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
brain
frontal and temporal cortex
Homo sapiens
-
2.6.1.7
frontal lobe
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + 2-oxoglutarate
KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate
636627
Homo sapiens
kynurenic acid + L-glutamate + H2O
-
636627
Homo sapiens
-
2.6.1.7
L-kynurenine + 2-oxoisohexanoate
KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate
636627
Homo sapiens
kynurenic acid + 2-aminoisohexanoate + H2O
-
636627
Homo sapiens
?
2.6.1.7
L-kynurenine + pyruvate
KAT I shows far higher activity with 2-oxoisohexanoate and pyruvate than with 2-oxoglutarate
636627
Homo sapiens
kynurenic acid + L-alanine + H2O
-
636627
Homo sapiens
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.6.1.7
7
8
KAT II from brain
Homo sapiens
2.6.1.7
9.6
10
KAT I from brain, sharp optimum
Homo sapiens