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Literature summary extracted from

  • Malherbe, P.; Alberati-Giani, D.; Koehler, C.; Cesura, A.M.
    Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain (1995), FEBS Lett., 367, 141-144.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.7 transient expression in HEK-293 cells Rattus norvegicus
2.6.1.64 cDNA clone encoding KAT/GTK, transfection of HEK-293 cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.7 0.096
-
 2-oxoglutarate pH 8.0, 37°C, recombinant mitochondrial enzyme Rattus norvegicus
2.6.1.7 1.63
-
 pyruvate pH 8.0, 37°C, recombinant mitochondrial enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.7 mitochondrion cDNA encodes for a kynurenine aminotransferase that is identical to a soluble form but carries an additional stretch of 32 amino acids resembling a mitochondrial import sequence Rattus norvegicus 5739
-
2.6.1.64 cytosol
-
 Rattus norvegicus 5829
-
2.6.1.64 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Rattus norvegicus Q08415 brain KAT I
-
2.6.1.64 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.7 brain
-
 Rattus norvegicus
-
2.6.1.64 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate enzyme has both kynurenine aminotransferase and glutamine transaminase K activity Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?
2.6.1.7 L-kynurenine + pyruvate
-
 Rattus norvegicus kynurenic acid + L-alanine + H2O
-
 ?
2.6.1.64 additional information cysteine S-conjugate beta-lyase activity, identical with kynurenine pyruvate aminotransferase Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.7 KAT
-
 Rattus norvegicus
2.6.1.64 EC 2.6.1.14 maybe identical Rattus norvegicus
2.6.1.64 EC 2.6.1.7 maybe identical Rattus norvegicus
2.6.1.64 KAT/GTK
-
 Rattus norvegicus
2.6.1.64 kynurenine aminotransferase/glutamine transaminase K
-
 Rattus norvegicus