BRENDA - Enzyme Database

Effects of calcium ions and quinolinic acid on rat kidney mitochondrial kynurenine aminotransferase

Mason, M.; Biochem. Biophys. Res. Commun. 60, 64-69 (1974)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
EGTA
strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM
Rattus norvegicus
2.6.1.7
additional information
not inhibited by EGTA; not inhibited by quinolinate
Rattus norvegicus
2.6.1.7
quinolinic acid
strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.6.1.7
mitochondrion
-
Rattus norvegicus
5739
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.6.1.7
CaCl2
approx. 4fold increase in activity at pH 6.4
Rattus norvegicus
2.6.1.7
additional information
not activated by chloride salts of Mg2+, Mn2+, Na+, K+ or NH4+
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.6.1.7
Rattus norvegicus
-
Sprague-Dawley
-
2.6.1.7
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + 2-oxoglutarate
-
636612
Rattus norvegicus
kynurenic acid + L-glutamate + H2O
-
636612
Rattus norvegicus
-
2.6.1.7
L-kynurenine + 2-oxoglutarate
-
636612
Rattus norvegicus Sprague-Dawley
kynurenic acid + L-glutamate + H2O
-
636612
Rattus norvegicus Sprague-Dawley
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
EGTA
strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM
Rattus norvegicus
2.6.1.7
additional information
not inhibited by EGTA; not inhibited by quinolinate
Rattus norvegicus
2.6.1.7
quinolinic acid
strong inhibition at pH 6.8 and Ca2+ concentrations below 0.5 mM
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.6.1.7
mitochondrion
-
Rattus norvegicus
5739
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.6.1.7
CaCl2
approx. 4fold increase in activity at pH 6.4
Rattus norvegicus
2.6.1.7
additional information
not activated by chloride salts of Mg2+, Mn2+, Na+, K+ or NH4+
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-kynurenine + 2-oxoglutarate
-
636612
Rattus norvegicus
kynurenic acid + L-glutamate + H2O
-
636612
Rattus norvegicus
-
2.6.1.7
L-kynurenine + 2-oxoglutarate
-
636612
Rattus norvegicus Sprague-Dawley
kynurenic acid + L-glutamate + H2O
-
636612
Rattus norvegicus Sprague-Dawley
-