BRENDA - Enzyme Database

Studies on the kynurenine adminotransferase activity in rat liver and kidney

De Antoni, A.; Costa, C.; Allegri, G.; Hoppe-Seyler's Z. Physiol. Chem. 357, 1707-1712 (1976)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
L-kynurenine
substrate inhibition above 6 mM
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.6.1.7
2.5
-
L-3-hydroxykynurenine
pH 7.2, 37C, kidney mitochondria
Rattus norvegicus
2.6.1.7
2.5
-
L-kynurenine
pH 7.2, 37C, kidney supernatant
Rattus norvegicus
2.6.1.7
3
-
L-kynurenine
pH 7.2, 37C, liver supernatant
Rattus norvegicus
2.6.1.7
3.4
-
L-kynurenine
pH 7.2, 37C, kidney mitochondria
Rattus norvegicus
2.6.1.7
5
-
L-3-hydroxykynurenine
pH 7.2, 37C, liver supernatant
Rattus norvegicus
2.6.1.7
5
-
L-kynurenine
pH 7.2, 37C, liver mitochondria
Rattus norvegicus
2.6.1.7
5.3
-
L-3-hydroxykynurenine
pH 7.2, 37C, kidney supernatant
Rattus norvegicus
2.6.1.7
6.3
-
L-3-hydroxykynurenine
pH 7.2, 37C, liver mitochondria
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.6.1.7
mitochondrion
40% of kidney total activity; 80% of liver total activity
Rattus norvegicus
5739
-
2.6.1.7
additional information
subcellular distribution
Rattus norvegicus
-
-
2.6.1.7
soluble
60% of kidney total activity
Rattus norvegicus
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.6.1.7
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
kidney
-
Rattus norvegicus
-
2.6.1.7
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-3-hydroxykynurenine + 2-oxoglutarate
-
636609
Rattus norvegicus
xanthurenic acid + L-glutamate
-
636609
Rattus norvegicus
-
2.6.1.7
L-kynurenine + 2-oxoglutarate
-
636609
Rattus norvegicus
kynurenic acid + L-glutamate + H2O
-
636609
Rattus norvegicus
-
Temperature Optimum [C]
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.6.1.7
37
-
assay at
Rattus norvegicus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.6.1.7
pyridoxal 5'-phosphate
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.6.1.7
pyridoxal 5'-phosphate
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.6.1.7
L-kynurenine
substrate inhibition above 6 mM
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.6.1.7
2.5
-
L-3-hydroxykynurenine
pH 7.2, 37C, kidney mitochondria
Rattus norvegicus
2.6.1.7
2.5
-
L-kynurenine
pH 7.2, 37C, kidney supernatant
Rattus norvegicus
2.6.1.7
3
-
L-kynurenine
pH 7.2, 37C, liver supernatant
Rattus norvegicus
2.6.1.7
3.4
-
L-kynurenine
pH 7.2, 37C, kidney mitochondria
Rattus norvegicus
2.6.1.7
5
-
L-3-hydroxykynurenine
pH 7.2, 37C, liver supernatant
Rattus norvegicus
2.6.1.7
5
-
L-kynurenine
pH 7.2, 37C, liver mitochondria
Rattus norvegicus
2.6.1.7
5.3
-
L-3-hydroxykynurenine
pH 7.2, 37C, kidney supernatant
Rattus norvegicus
2.6.1.7
6.3
-
L-3-hydroxykynurenine
pH 7.2, 37C, liver mitochondria
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.6.1.7
mitochondrion
40% of kidney total activity; 80% of liver total activity
Rattus norvegicus
5739
-
2.6.1.7
additional information
subcellular distribution
Rattus norvegicus
-
-
2.6.1.7
soluble
60% of kidney total activity
Rattus norvegicus
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.6.1.7
kidney
-
Rattus norvegicus
-
2.6.1.7
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.6.1.7
L-3-hydroxykynurenine + 2-oxoglutarate
-
636609
Rattus norvegicus
xanthurenic acid + L-glutamate
-
636609
Rattus norvegicus
-
2.6.1.7
L-kynurenine + 2-oxoglutarate
-
636609
Rattus norvegicus
kynurenic acid + L-glutamate + H2O
-
636609
Rattus norvegicus
-
Temperature Optimum [C] (protein specific)
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.6.1.7
37
-
assay at
Rattus norvegicus