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Literature summary extracted from

  • De Antoni, A.; Costa, C.; Allegri, G.
    Studies on the kynurenine adminotransferase activity in rat liver and kidney (1976), Hoppe-Seyler's Z. Physiol. Chem., 357, 1707-1712.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 L-kynurenine substrate inhibition above 6 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.7 2.5
-
 L-3-hydroxykynurenine pH 7.2, 37°C, kidney mitochondria Rattus norvegicus
2.6.1.7 2.5
-
 L-kynurenine pH 7.2, 37°C, kidney supernatant Rattus norvegicus
2.6.1.7 3
-
 L-kynurenine pH 7.2, 37°C, liver supernatant Rattus norvegicus
2.6.1.7 3.4
-
 L-kynurenine pH 7.2, 37°C, kidney mitochondria Rattus norvegicus
2.6.1.7 5
-
 L-kynurenine pH 7.2, 37°C, liver mitochondria Rattus norvegicus
2.6.1.7 5
-
 L-3-hydroxykynurenine pH 7.2, 37°C, liver supernatant Rattus norvegicus
2.6.1.7 5.3
-
 L-3-hydroxykynurenine pH 7.2, 37°C, kidney supernatant Rattus norvegicus
2.6.1.7 6.3
-
 L-3-hydroxykynurenine pH 7.2, 37°C, liver mitochondria Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.7 mitochondrion 80% of liver total activity Rattus norvegicus 5739
-
2.6.1.7 mitochondrion 40% of kidney total activity Rattus norvegicus 5739
-
2.6.1.7 additional information subcellular distribution Rattus norvegicus
-
-
2.6.1.7 soluble 60% of kidney total activity Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.7 kidney
-
 Rattus norvegicus
-
2.6.1.7 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-3-hydroxykynurenine + 2-oxoglutarate
-
 Rattus norvegicus xanthurenic acid + L-glutamate
-
 ?
2.6.1.7 L-kynurenine + 2-oxoglutarate
-
 Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.7 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Rattus norvegicus