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Literature summary extracted from

  • Carvalho, D.P.; Dupuy, C.; Gorin, Y.; Legue, O.; Pommier, J.; Haye, B.; Virion, A.
    The Ca2+- and reduced nicotinamide adenine dinucleotide phosphate-dependent hydrogen peroxide generating system is induced by thyrotropin in porcine thyroid cells (1996), Endocrinology, 137, 1007-1012.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 8-bromo-cAMP can replace for thyrotropin Sus scrofa
1.6.3.1 forskolin can replace thyrotropin Sus scrofa
1.6.3.1 additional information upregulated by agents activationg cAMP pathway Sus scrofa
1.6.3.1 thyrotropin almost no activity in cells grown without Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.3.1 0.015
-
 NADPH pH 7.2, 30°C, 1.5 mM Ca2+ Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.6.3.1 Ca2+ regulates enzyme activity Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 thyroid gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2
-
 Sus scrofa NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
 ?