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Literature summary extracted from

  • Leseney, A.M.; Deme, D.; Legue, O.; Ohayon, R.; Chanson, P.; Sales, J.P.; Pires de Carvalho, D.; Dupuy, C.; Virion, A.
    Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue (1999), Biochimie, 81, 373-380.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 phosphate
-
 Homo sapiens
1.6.3.1 phosphate
-
 Sus scrofa
1.6.3.1 thyrotropin
-
 Homo sapiens
1.6.3.1 thyrotropin
-
 Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 additional information unidentified inhibitor found in 3000 g particulate fraction from patients with Grave's disease Homo sapiens
1.6.3.1 additional information
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.3.1 0.01
-
 NADPH pH 7.4, 30°C, 1.5 mM Ca2+ Sus scrofa
1.6.3.1 0.1
-
 NADPH pH 7.4, 30°C, 1.5 mM Ca2+, patients with Grave's disease Homo sapiens
1.6.3.1 0.1
-
 NADH pH 7.4, 30°C, 1.5 mM Ca2+, patients with Grave's disease Homo sapiens
1.6.3.1 0.2
-
 NADH pH 7.4, 30°C, 1.5 mM Ca2+ Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.6.3.1 Ca2+ regulates enzyme activity Homo sapiens
1.6.3.1 Ca2+ regulates enzyme activity Sus scrofa
1.6.3.1 Ca2+ no activity without Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 Homo sapiens involved in Grave's disease NAD(P)+ + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Homo sapiens
-
 female
-
1.6.3.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 thyroid gland
-
 Homo sapiens
-
1.6.3.1 thyroid gland
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.3.1 0.002
-
 pH 7.4, 30°C, 1.5 mM Ca2+, saturating concentration of NADPH Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2
-
 Homo sapiens NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2
-
 Sus scrofa NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 involved in Grave's disease Homo sapiens NAD(P)+ + H2O2
-
 ?
1.6.3.1 NADH + H+ + O2
-
 Homo sapiens NAD+ + H2O2
-
 ?
1.6.3.1 NADH + H+ + O2
-
 Sus scrofa NAD+ + H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.3.1 FAD
-
 Homo sapiens
1.6.3.1 FAD
-
 Sus scrofa
1.6.3.1 FMN can replace for FAD Homo sapiens
1.6.3.1 NADH can replace NADPH Homo sapiens
1.6.3.1 NADPH
-
 Homo sapiens
1.6.3.1 NADPH
-
 Sus scrofa