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Literature summary extracted from

  • Puskas, F.; Braun, L.; Csala, M.; Kardon, T.; Marcolongo, P.; Benedetti, A.; Mandl, J.; Banhegyi, G.
    Gulonolactone oxidase activity-dependent intravesicular glutathione oxidation in rat liver microsomes (1998), FEBS Lett., 430, 293-296.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.3.8 alamethicin 0.1 mg per mg protein 7.5% activation Rattus norvegicus
1.1.3.8 Triton X-100 addition to intact microsomes results in a concentration dependent increase in gulonolactone oxidase activity, 38% activation with 5 mg Triton X-100 per mg protein Rattus norvegicus

General Stability

EC Number General Stability Organism
1.1.3.8 highly resistant to proteolytic treatment both in native and in disrupted microsomes Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.3.8 microsome integral membrane protein in the endoplasmic reticulum Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.3.8 L-gulono-1,4-lactone + O2 Rattus norvegicus
-
 L-xylo-hex-3-ulonolactone + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.3.8 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.3.8 L-gulono-1,4-lactone + O2 = L-xylo-hex-2-ulono-1,4-lactone + H2O2 product isomerizes spontaneously to L-ascorbate Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.3.8 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Rattus norvegicus L-xylo-hex-3-ulonolactone + H2O2
-
 ?
1.1.3.8 L-gulono-1,4-lactone + O2
-
 Rattus norvegicus L-xylo-hex-3-ulonolactone + H2O2 product isomerizes spontaneously to L-ascorbate ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.3.8 37
-
-
 Rattus norvegicus