BRENDA - Enzyme Database

Enzymic synthesis of 3-halogenoaspartic acids using beta-methylaspartase: Inhibition by 3-bromoaspartic acid

Akhtar, M.; Cohen, M.A.; Gani, D.; J. Chem. Soc. Chem. Commun. 1986, 1290-1291 (1980)
No PubMed abstract available

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
4.3.1.2
synthesis
enzyme is used for L-aspartic acid production
Clostridium tetanomorphum
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.3.1.2
3-bromoaspartate
irreversible
Clostridium tetanomorphum
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.3.1.2
L-threo-3-methylaspartate
Clostridium tetanomorphum
-
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.3.1.2
Clostridium tetanomorphum
-
-
-
Reaction
EC Number
Reaction
Commentary
Organism
4.3.1.2
L-threo-3-methylaspartate = mesaconate + NH3
mechanism
Clostridium tetanomorphum
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.1.2
3-bromoaspartate
-
6053
Clostridium tetanomorphum
bromofumarate + NH3
during reaction, enzyme becomes inactive. This is reduced in the presence of alternative substrates
6053
Clostridium tetanomorphum
-
4.3.1.2
3-chloroaspartate
-
6053
Clostridium tetanomorphum
chlorofumarate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-aspartate
(2S)-aspartate
6053
Clostridium tetanomorphum
fumarate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-threo-3-methylaspartate
r
6053
Clostridium tetanomorphum
mesaconate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-threo-3-methylaspartate
(2S,3S)-3-methylaspartic acid
6053
Clostridium tetanomorphum
mesaconate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-threo-3-methylaspartate
-
6053
Clostridium tetanomorphum
?
-
-
-
-
Application (protein specific)
EC Number
Application
Commentary
Organism
4.3.1.2
synthesis
enzyme is used for L-aspartic acid production
Clostridium tetanomorphum
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.3.1.2
3-bromoaspartate
irreversible
Clostridium tetanomorphum
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.3.1.2
L-threo-3-methylaspartate
Clostridium tetanomorphum
-
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.3.1.2
3-bromoaspartate
-
6053
Clostridium tetanomorphum
bromofumarate + NH3
during reaction, enzyme becomes inactive. This is reduced in the presence of alternative substrates
6053
Clostridium tetanomorphum
-
4.3.1.2
3-chloroaspartate
-
6053
Clostridium tetanomorphum
chlorofumarate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-aspartate
(2S)-aspartate
6053
Clostridium tetanomorphum
fumarate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-threo-3-methylaspartate
r
6053
Clostridium tetanomorphum
mesaconate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-threo-3-methylaspartate
(2S,3S)-3-methylaspartic acid
6053
Clostridium tetanomorphum
mesaconate + NH3
-
6053
Clostridium tetanomorphum
-
4.3.1.2
L-threo-3-methylaspartate
-
6053
Clostridium tetanomorphum
?
-
-
-
-