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Literature summary extracted from

  • Rebrin, I.; Bailey, S.W.; Boerth, S.R.; Ardell, M.D.; Ayling, J.E.
    Catalytic characterization of 4alpha-hydroxytetrahydropterin dehydratase (1995), Biochemistry, 34, 5801-5810.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.2.1.96 Quinoid 6(S)-methyldihydropterin
-
 Rattus norvegicus
4.2.1.96 Quinoid 6(S)-propyldihydropterin
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2.1.96 0.0015
-
 4a(R)-hydroxy-6(S)-propyltetrahydropterin pH 8.4 or pH 7.4 Rattus norvegicus
4.2.1.96 0.0025
-
 4a-Hydroxy-6(S)-methyltetrahydropterin pH 8.4 or pH 7.4 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.96 additional information contains no metals Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.96 additional information Rattus norvegicus the enzyme is essential in vivo to prevent rearrangement of 4a-hydroxy-6(R)-tetrahydrobiopterin and to maintain the supply of tetrahydrobiopterin cofactor for hydroxylases under conditions where the nonenzymatic rate would be inadequate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.96 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.96 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.96 4a(R)-hydroxy-6(S)-propyltetrahydropterin
-
 Rattus norvegicus quinoid 6(S)-propyldihydropterin
-
 ?
4.2.1.96 4a-Hydroxy-6(R)-dihydroxypropyltetrahydropterin
-
 Rattus norvegicus ?
-
 ?
4.2.1.96 4a-Hydroxy-6(S)-methyltetrahydropterin
-
 Rattus norvegicus Quinoid 6(S)-methyldihydropterin
-
 ?
4.2.1.96 4a-Hydroxy-6(S)-propyltetrahydropterin
-
 Rattus norvegicus Quinoid 6(S)-propyldihydropterin
-
 ?
4.2.1.96 additional information the enzyme is essential in vivo to prevent rearrangement of 4a-hydroxy-6(R)-tetrahydrobiopterin and to maintain the supply of tetrahydrobiopterin cofactor for hydroxylases under conditions where the nonenzymatic rate would be inadequate Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.1.96 More the enzyme has identical amino acid sequence to DCoH, the dimerization cofactor of the transcription regulator, HNF-1alpha Rattus norvegicus