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Literature summary extracted from

  • Brady, D.R.; Houston, L.L.
    Some properties of the catalytic sites of imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase, a bifunctional enzyme from Salmonella typhimurium (1973), J. Biol. Chem., 248, 2588-2592.
    View publication on PubMed

General Stability

EC Number General Stability Organism
4.2.1.19 Mn2+ stabilizes Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.15 histidine
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.1.3.15 histidinol
-
 Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.19 3-Amino-1,2,4-triazole
-
 Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.19 phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.19 Zn2+
-
 Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.15 0.3
-
 L-histidinol phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.1.19 Mn2+ Km: 0.0073 mM Salmonella enterica subsp. enterica serovar Typhimurium

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.15 75000
-
 gel filtration Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.15 L-histidinol phosphate + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.15 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
4.2.1.19 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.15
-
 Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.19
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

EC Number Reaction Comment Organism Reaction ID
4.2.1.19 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O energy of activation 14700 cal/mol Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.15 L-histidinol phosphate + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-histidinol + phosphate
-
 ?
3.1.3.15 L-histidinol phosphate + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
4.2.1.19 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.3.15 54
-
 50% loss of phosphatase activity in 2 min Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.19 54
-
 16 min, stable Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.15 6.5 7
-
 Salmonella enterica subsp. enterica serovar Typhimurium
4.2.1.19 7.5
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.15 4.5 9
-
 Salmonella enterica subsp. enterica serovar Typhimurium